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KM11060

CAT: 0013-GTR19162324-07Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19162324-07Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent corrector of the F508del-CFTR trafficking defect that partially restores F508del trafficking and increases maturation significantly in BHK cells (10 nM for 24 h or 10 uM for 2 h) ; also can significantly increase plasma lipoxin A4 levels in F508del relevant to wildtype mice.
CAS Number
774549-97-2
Product Name Alternative
KM 11060 | KM-11060
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
O=S (N1CCN (C2=CC=NC3=CC (Cl) =CC=C23) CC1) (C4=CC=C (Cl) C=C4) =O
Molecular Formula
C19H17Cl2N3O2S
Molecular Weight
422.3282
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Quinoline, 7-chloro-4-[4-[ (4-chlorophenyl) sulfonyl]-1-piperazinyl]-

Chemical Information

KM11060
CAS Number774549-97-2
PubChem CID1241327
IUPAC Name7-chloro-4-[4-(4-chlorophenyl)sulfonylpiperazin-1-yl]quinoline
Molecular FormulaC19H17Cl2N3O2S
Molecular Weight422.3
XLogP4.2
Topological Polar Surface Area61.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Heavy Atom Count27
Formal Charge0
Complexity599
SMILES
C1CN(CCN1C2=C3C=CC(=CC3=NC=C2)Cl)S(=O)(=O)C4=CC=C(C=C4)Cl
InChI
InChI=1S/C19H17Cl2N3O2S/c20-14-1-4-16(5-2-14)27(25,26)24-11-9-23(10-12-24)19-7-8-22-18-13-15(21)3-6-17(18)19/h1-8,13H,9-12H2
InChIKey
GIEHIZKCIZLXLF-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of KM11060
CAS: 774549-97-2
CID: 1241327
Formula: C19H17Cl2N3O2S
MW: 422.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight422.3
XLogP34.2
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count3
Exact Mass421.0418534
Monoisotopic Mass421.0418534
Topological Polar Surface Area61.9 Ų
Heavy Atom Count27
Formal Charge0
Complexity599
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
MBS578191KM11060

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