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Cilastatin

CAT: 0013-GTR19161545-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161545-01Size:500 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A renal dehydropeptidase-I and leukotriene D4 dipeptidase inhibitor. Since the antibiotic, imipenem, is hydrolyzed by dehydropeptidase-I, which resides in the brush border of the renal tubule, cilastatin is administered with imipenem to increase its effectiveness. The drug also inhibits the metabolism of leukotriene D4 to leukotriene E4. (In Vitro) :Cilastatin (200 μg/mL; 24 hours; RPTECs) treatment protects against Vancomycin-induced proximal tubule apoptosis and increases cell viability, without compromising the antimicrobial effect of Vancomycin. (In Vivo) :In a mouse model (female mice, strain CD-1, 20 g) of systemic infection, Imipenem plus Cilastatin can protect mice from S. aureus, E. coli, and P. aeruginosa infection.
CAS Number
82009-34-5
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
CC1 (C[C@H]1C (=O) N/C (=C\CCCCSC[C@H] (C (=O) O) N) /C (=O) O) C
Molecular Formula
C16H26N2O5S
Molecular Weight
358.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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