Lamotrigine

CAT: 0013-GTR19161489-02Size: 500 mgDry Ice: NoHazardous: No

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Description

Lamotrigine is an anticonvulsant drug used in the treatment of epilepsy and bipolar disorder. For epilepsy it is used to treat partial seizures, primary and secondary tonic-clonic seizures, and seizures associated with Lennox-Gastaut syndrome. Lamotrigine also acts as a mood stabilizer. It is the first medication since lithium granted Food and Drug Administration (FDA) approval for the maintenance treatment of bipolar type I. Chemically unrelated to other anticonvulsants, lamotrigine has relatively few side-effects and does not require blood monitoring. (In Vitro) :Lamotrigine inhibits Veratrine evoked release of glutamate and aspartate with ED50 values of 21 μM for both amino acids, but Lamotrigine is less potent in the inhibition of GABA release (ED50=44 μM. At concentrations up to 300 μM, LTG has no effect on patassium-evoked amino acid.Lamotrigine is some five times less potent in the inhibition of Veratrine-evoked [3H]acetylcholine release (ED50=100 μM) than in glutamate or aspartate release. (In Vivo) :Lamotrigine (IP, 30 min before pentylenetetrazol; 10 mg/kg, 15 mg/kg or 20 mg/kg) decreases the seizure intensity at the higher doses, it increases the latency to the first pentylenetetrazol-induced seizure in all studied doses compared with the controls.

CAS Number

84057-84-1

Product Name Alternative

BW 430C | Epilepax | Lamictal | LTG

Field of Research

Pharmacology & Drug Discovery

Purity

>98% (HPLC)

Solubility

Ethanol: 3 mg/mL (11.71 mM) ; DMSO: 10 mg/mL (39.04 mM)

Smiles

NC1=NC (N) =C (C2=CC=CC (Cl) =C2Cl) N=N1

Molecular Formula

C9H7Cl2N5

Molecular Weight

256.09

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

6- (2,3-dichlorophenyl) -1,2,4-triazine-3,5-diamine

Chemical Information

Lamotrigine

Lamotrigine is a member of the class of 1,2,4-triazines in which the triazene skeleton is substituted by amino groups at positions 3 and 5, and by a 2,3-dichlorophenyl group at position 6. It has a role as a geroprotector, an antidepressant, an antimanic drug, a non-narcotic analgesic, an anticonvulsant, a xenobiotic, a calcium channel blocker, an excitatory amino acid antagonist, an EC 3.4.21.26 (prolyl oligopeptidase) inhibitor and an environmental contaminant. It is a dichlorobenzene, a member of 1,2,4-triazines and a primary arylamine.

CAS Number	84057-84-1
PubChem CID	3878
IUPAC Name	6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
Molecular Formula	C9H7Cl2N5
Molecular Weight	256.09
XLogP	1.4
Topological Polar Surface Area	90.7
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Heavy Atom Count	16
Formal Charge	0
Complexity	242

SMILES

C1=CC(=C(C(=C1)Cl)Cl)C2=C(N=C(N=N2)N)N

InChI

InChI=1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)

InChIKey

PYZRQGJRPPTADH-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 84057-84-1

CID: 3878

Formula: C9H7Cl2N5

MW: 256.09

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	256.09
XLogP3	1.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	1
Exact Mass	255.0078506
Monoisotopic Mass	255.0078506
Topological Polar Surface Area	90.7 Å²
Heavy Atom Count	16
Formal Charge	0
Complexity	242
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Alternative Products

Catalog	Name
B1234-50	Lamotrigine

Lamotrigine

Chemical Information

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