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Pyrimethamine

CAT: 0013-GTR19161387-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161387-01Size:500 mg
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Description
A synthetic derivative of ethyl-pyrimidine with potent antimalarial properties; interferes with the regeneration of tetrahydrofolic acid from dihydrofolate by competitively inhibiting DHFR; has also been found to reduce the expression of SOD1.Parasite Infection Approved (In Vitro) :Pyrimethamine (Pirimecidan; 4 nM-4 μM; 24 h; LLC-MK2 cells with T. gondii) combination of Fluconazole (FLZ) (HY-B0101) inhibits T. gondii activity with IC50 values of 0.23, 0.19, 0.23, 0.34, 0.14, and 0.19 μM for FLZ concentration at 0, 0.05, 0.1, 0.5, 1.0, and 3.0 μM, respectively.
CAS Number
58-14-0
Product Name Alternative
Pirimecidan | Pirimetamin | RP 4753
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCC1=C (C (=NC (=N1) N) N) C2=CC=C (C=C2) Cl
Molecular Formula
C12H13ClN4
Molecular Weight
248.7114
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Pyrimidinediamine, 5- (4-chlorophenyl) -6-ethyl-

Alternative Products

CatalogName
A4353-10Pyrimethamine

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