IOX1

CAT: 0013-GTR19161376-01Size: 200 mgDry Ice: NoHazardous: No

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CAT#:0013-GTR19161376-01Size:200 mg

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Description

IOX1 is a potent, broad-spectrum inhibitor of 2OG oxygenases, including the JmjC demethylases, with IC50 of <1 uM gainst the KDM3, KDM4 and KDM6, 5-25 uM against the KDM5 and KDM2/7; IOX1 is less potent against BBOX1 (IC50=196 uM) ; chelates to Fe (II) in the active site of 2OG oxygenases; suppresses the proliferation and migration of vascular smooth muscle cells induced by angiotensin II.

CAS Number

5852-78-8

Product Name Alternative

IOX 1 | IOX-1

Purity

>98% (HPLC)

Solubility

DMSO: 24 mg/mL

Smiles

O=C (C1=C2C=CC=NC2=C (O) C=C1) O

Molecular Formula

C10H7NO3

Molecular Weight

189.1675

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

5-Quinolinecarboxylic acid, 8-hydroxy-

Chemical Information

8-Hydroxy-5-quinolinecarboxylic acid

8-hydroxy-5-quinolinecarboxylic acid is a member of quinolines.

CAS Number	5852-78-8
PubChem CID	459617
IUPAC Name	8-hydroxyquinoline-5-carboxylic acid
Molecular Formula	C10H7NO3
Molecular Weight	189.17
XLogP	1.8
Topological Polar Surface Area	70.4
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Heavy Atom Count	14
Formal Charge	0
Complexity	231

SMILES

C1=CC2=C(C=CC(=C2N=C1)O)C(=O)O

InChI

InChI=1S/C10H7NO3/c12-8-4-3-7(10(13)14)6-2-1-5-11-9(6)8/h1-5,12H,(H,13,14)

InChIKey

JGRPKOGHYBAVMW-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 5852-78-8

CID: 459617

Formula: C10H7NO3

MW: 189.17

Interactive 3D Structure

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View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	189.17
XLogP3	1.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	1
Exact Mass	189.042593085
Monoisotopic Mass	189.042593085
Topological Polar Surface Area	70.4 Å²
Heavy Atom Count	14
Formal Charge	0
Complexity	231
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
GTR19262364-01	IOX5
GTR19167310-01	IOX4
GTR19178021-01	IOX2
GTR19169826-01	IOX 1
GTR19160756-01	IOX 2

Alternative Products

Catalog	Name
2266-25	IOX1
A14277-25	IOX1 25mg
A14277-10	IOX1 10mg
A14277-5	IOX1 5mg
A14277-50	IOX1 50mg

IOX1

Chemical Information

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