Products for Research Use Only
RegisterLogin

IOX 2

CAT: 0013-GTR19160756-01Size: 200 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19160756-01Size:200 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
IOX2 is a selective inhibitor of the Hypoxia Inducible Factor (HIF) Prolyl-Hydroxylases (PHD) ; active in cells with IC50 value of 21 nM for PHD2/ELGN-1 and no inhibition at FIH (20uM) . (In Vitro) :IOX2 (0, 10, 25, and 50 μM) dose-dependently inhibits collagen-related peptide (CRP; 0.25 μg/mL) or thrombin (0.03 U/mL) -induced platelet aggregation and ATP release. But IOX2 doesn’t affect P-selectin expression and the surface levels of glycoprotein (GP) Ibα, GPVI, or αIIbβ3.IOX2 also inhibits the spreading of platelets on fibrinogen or collagen and clot retraction.IOX2 (50 μM; 24 h) increases the transcription level of VEGF-A and BNIP3 in Normal human epidermal keratinocytes (NHEK) and Normal human dermal fibroblasts (NHDF), when grown under normoxia and hypoxia condition. (In Vivo) :IOX2 (10 mg/kg; i.p.; single dose) impaired the in vivo hemostatic function of platelets and arterial thrombus formation in mice.
CAS Number
931398-72-0
Product Name Alternative
IOX2 | IOX-2 | IOX 2
Purity
>98% (HPLC)
Solubility
DMSO: 7 mg/mL (19.86 mM)
Smiles
O=C (O) CNC (C1=C (O) C2=C (N (CC3=CC=CC=C3) C1=O) C=CC=C2) =O
Molecular Formula
C19H16N2O5
Molecular Weight
352.34
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N-[[1,2-Dihydro-4-hydroxy-2-oxo-1- (phenylmethyl) -3-quinolinyl]carbonyl]glycine

Chemical Information

N-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine

2-[[[4-hydroxy-2-oxo-1-(phenylmethyl)-3-quinolinyl]-oxomethyl]amino]acetic acid is a member of quinolines.

CAS Number931398-72-0
PubChem CID54685215
IUPAC Name2-[(1-benzyl-4-hydroxy-2-oxoquinoline-3-carbonyl)amino]acetic acid
Molecular FormulaC19H16N2O5
Molecular Weight352.3
XLogP2.6
Topological Polar Surface Area107
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count26
Formal Charge0
Complexity609
SMILES
C1=CC=C(C=C1)CN2C3=CC=CC=C3C(=C(C2=O)C(=O)NCC(=O)O)O
InChI
InChI=1S/C19H16N2O5/c22-15(23)10-20-18(25)16-17(24)13-8-4-5-9-14(13)21(19(16)26)11-12-6-2-1-3-7-12/h1-9,24H,10-11H2,(H,20,25)(H,22,23)
InChIKey
CAOSCCRYLYQBES-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of N-(1-Benzyl-4-hydroxy-2-oxo-1,2-dihydroquinoline-3-carbonyl)glycine
CAS: 931398-72-0
CID: 54685215
Formula: C19H16N2O5
MW: 352.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight352.3
XLogP32.6
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass352.10592162
Monoisotopic Mass352.10592162
Topological Polar Surface Area107 Ų
Heavy Atom Count26
Formal Charge0
Complexity609
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Related Products

CatalogName
GTR19169826-01IOX 1
GTR19262364-01IOX5
GTR19167310-01IOX4
GTR19161376-01IOX1
GTR19178021-01IOX2
GTR19170856-012,2,2-Trichloroethanol
GTR19216509-012,2,2-Trichloroethanol
GTR19255109-012,2,2-Trifluoroacetamide
GTR19228240-012-[2- (2,2,2-Trifluoroethoxy) phenoxy]ethyl bromide
GTR19166705-012-[2- (2,2,2-Trifluoroethoxy) phenoxy]ethyl methanesulfonate

Alternative Products

CatalogName
303-150Riboclear (RNA Cleanup)
TBS10485-100Tribio InVivoMAb Anti-Mouse TIGIT & PD-L1 Bispecific Antibody
TBS10191-1mgTetrahydrocannabinol (THC) Monoclonal Antibody
TBI3024-25MGAc-Leu-Leu-Nle-CHO (ALLN), Calpain inhibitor
122-101ExgeneTM Forensic SV mini
TBS10483-100Tribio InVivoMAb Anti-Mouse PD-L1 & CD28 Bispecific Antibody
TBS10183-1mgMonoclonal Anti-Thyroid Stimulating Hormone (TSH) Antibody
TBS10340-0.5MGInVivo Mouse IgG1 Isotype Control Antibody
121-220Exfection Plasmid EF (Exdotoxin Free, Midi)
TBS10482-100Tribio InVivoMAb Anti-Mouse PD-L1 & OX40 Bispecific Antibody

Popular Products