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CP 640186

CAT: 0013-GTR19161339-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161339-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CP-640186 is an isozyme-nonselective Acetyl-CoA carboxylase (ACCase) inhibitor with IC50s of 53 nM and 61 nM for rat liver ACC1 and rat skeletal muscle ACC2 respectively; with improved metabolic stability vs CP-610431. (In Vitro) :CP-640186 (20 μM; 48 h) treatment can inhibit H460 cell growth.CP-640186 (0.1 nM-100 μM; 2 h) treatment increases fatty acid metabolism in a concentration-dependent manner in C2C12 cells and muscle strips.CP-640186 (0.62-1.8 μM; 2 h) treatment inhibits fatty acid synthesis and TG synthesis in HepG2 cells. (In Vivo) :CP-640186 (oral gavage; 4.6-21 mg/kg; once) demonstrates acute efficacy.CP-640186 (intravenous injection and oral gavage; Intravenous dose, 5 mg/kg; oral dose, 10 mg/kg; once) shows lowe drug exposure in the rat than the ob/ob mouse at equal doses.CP-640186 (oral gavage; 100 mg/kg; once) treatment shows a complete shift from carbohydrate utilization to fatty acid utilization as a source of energy at high exposure level.
CAS Number
591778-68-6
Purity
>98% (HPLC)
Solubility
DMSO: 10 mM
Smiles
C1C[C@H] (CN (C1) C2CCN (CC2) C (=O) C3=C4C=CC=CC4=CC5=CC=CC=C53) C (=O) N6CCOCC6
Molecular Formula
C30H35N3O3
Molecular Weight
485.62
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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Alternative Products

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T1889-01CP-640186
TRC-C591780-100MGCP 640186
RYA77870CP-640186 hydrochloride
HY-15259A-01CP-640186 (hydrochloride)
A13134-100CP-640186 100mg
A13134-2CP-640186 2mg

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