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PIK-93

CAT: 0013-GTR19161332-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161332-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PIK-93 is a potent, synthetic PI4K inhibitor with IC50 of 19 nM (PI4KIIIβ), also inhibits PI3Kγ and PI3Kα with IC50 of 16 nM and 39 nM, respectively; also inhibits other PI3Ks, including PI3Kα, β, and δ, with IC50 values of 39 nM, 0.59 uM, and 0.12 uM, shows no inhibitory effect against a panel of other kinases; significantly inhibits the conversion of [3H]serine-labeled endogenous ceramide to sphingomyelin, reduces carbachol-induced translocation of TRPC6 to the plasma membrane and net Ca2+ entry in T6.11 cells at 300 nM; also demonstrates anti-enterovirus effects by inhibition of both poliovirus and HCV replication with EC50 of 0.14 uM and 1.9 uM, respectively.
CAS Number
593960-11-3
Product Name Alternative
PIK 93 | PIK93
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (NC1=NC (C) =C (C2=CC=C (Cl) C (S (=O) (NCCO) =O) =C2) S1) =O
Molecular Formula
C14H16ClN3O4S2
Molecular Weight
389.8775
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Acetamide, N-[5-[4-chloro-3-[[ (2-hydroxyethyl) amino]sulfonyl]phenyl]-4-methyl-2-thiazolyl]-

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