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Azeliragon

CAT: 0013-GTR19161288-05Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161288-05Size:5 mg
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Description
An orally bioavailable small molecule inhibitor of RAGE; inhibits sRAGE from binding to RAGE ligands, S100b, amphoterin and carboxymethyl-lysine; has been shown to inhibit the binding of sRAGE to Aβ1-42 in a fluorescent polarization assay; reduces accumulation in the spleen of Aβ peptides and the expression of IL-6 and macrophage colony stimulating factor, reduces both inflammatory markers (TNF-α, TGF-β and IL-1) and CNS amyloid deposition.Alzheimer's Disease Phase 3 Clinical (In Vitro) :Azeliragon (4 nM; 16 hours; T cells) treatment inhibits of wild type mice (WT) but not the deletion of the receptor (RAGE-/- mice) T cells and significant reduction in the production of IFN-γ. (In Vivo) :Azeliragon (100 mcg/d; intraperitoneal injection; every day) treatment reduces syngeneic islet graft and islet allograft in NOD and B6 mice (Islets were isolated from young prediabetic NOD/LtJ mice and transplanted into NOD mice with spontaneous diabetes; islets were isolated from WT BALB/c mice and transplanted into B6 mice with diabetes) .
CAS Number
603148-36-3
Product Name Alternative
TTP-488 | PF-04494700
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CCCCC1=NC (=CN1C2=CC=C (C=C2) OC3=CC=C (C=C3) Cl) C4=CC=C (C=C4) OCCCN (CC) CC
Molecular Formula
C32H38ClN3O2
Molecular Weight
532.116
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-Propanamine, 3-[4-[2-butyl-1-[4- (4-chlorophenoxy) phenyl]-1H-imidazol-4-yl]phenoxy]-N, N-diethyl-

Chemical Information

3-(4-(2-Butyl-1-(4-(4-chlorophenoxy)phenyl)-1H-imidazol-4-yl)phenoxy)-N,N-diethyl-1-propanamine

Azeliragon has been used in trials studying the treatment of Alzheimer's Disease.

CAS Number603148-36-3
PubChem CID11180124
IUPAC Name3-[4-[2-butyl-1-[4-(4-chlorophenoxy)phenyl]imidazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine
Molecular FormulaC32H38ClN3O2
Molecular Weight532.1
XLogP8.3
Topological Polar Surface Area39.5
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count14
Heavy Atom Count38
Formal Charge0
Complexity626
SMILES
CCCCC1=NC(=CN1C2=CC=C(C=C2)OC3=CC=C(C=C3)Cl)C4=CC=C(C=C4)OCCCN(CC)CC
InChI
InChI=1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3
InChIKey
KJNNWYBAOPXVJY-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-(4-(2-Butyl-1-(4-(4-chlorophenoxy)phenyl)-1H-imidazol-4-yl)phenoxy)-N,N-diethyl-1-propanamine
CAS: 603148-36-3
CID: 11180124
Formula: C32H38ClN3O2
MW: 532.1
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight532.1
XLogP38.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count14
Exact Mass531.2652552
Monoisotopic Mass531.2652552
Topological Polar Surface Area39.5 Ų
Heavy Atom Count38
Formal Charge0
Complexity626
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
BA8408-10Azeliragon
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A20622-5Azeliragon 5mg
bs-7100C-01Azeliragon HCl
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HY-50682SAzeliragon-d9
HY-50682R-01Azeliragon (Standard)
HY-50682AAzeliragon (dihydrochloride)
A20622-25Azeliragon 25mg
A20622-10Azeliragon 10mg

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