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Cyclophosphamide hydrate

CAT: 0013-GTR19161278-02Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161278-02Size:100 mg
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Description
A synthetic alkylating agent chemically related to the nitrogen mustards with antineoplastic and immunosuppressive activities; used to treat cancers and autoimmune diseases.Chemotherapeutic Agents Approved (In Vitro) :Cyclophosphamide induces outer membrane blebbing, leads to DNA fragmentation, as revealed by TUNEL staining of free 3'-OH DNA ends, and induces cleavage of the caspase 3 and caspase 7 substrate PARP in 9L/P450 cells. Bcl-2 expression fully blocks the activation of both initiator caspases as well as the effector caspase 3 in cells treated with activated Cyclophosphamide. Bcl-2 inhibits the cytotoxic effects but not the cytostatic effects of activated Cyclophosphamide. Cyclophosphamide inhibits the AChE reversibly with an IC50 of 511 μM. Carbon tetrachloride does not affect the direct cytotoxicity of cyclophosphamide or 4-hydroxycyclophosphamide to cells in culture. (In Vivo) :Cyclophosphamide (injected i.p.;2mg/mouse in 0.1 mL PBS, in C3H mice bearing SW1 tumors) increases the percentage of cells that stained for CD3, CD4 or CD8 in both spleens and tumors.
CAS Number
6055-19-2
Product Name Alternative
Cyclophosphamide monohydrate
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 38 mg/mL
Smiles
O.ClCCN (CCCl) P1 (=O) NCCCO1
Molecular Formula
C7H17Cl2N2O3P
Molecular Weight
279.1012
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-1,3,2-Oxazaphosphorin-2-amine, N, N-bis (2-chloroethyl) tetrahydro-, 2-oxide, hydrate (1:1)

Chemical Information

Cyclophosphamide Monohydrate

Cyclophosphamide hydrate is the monohydrate of cyclophosphamide. It has a role as an alkylating agent, an antineoplastic agent, an immunosuppressive agent and a carcinogenic agent. It contains a cyclophosphamide.

CAS Number6055-19-2
PubChem CID22420
IUPAC NameN,N-bis(2-chloroethyl)-2-oxo-1,3,2lambda5-oxazaphosphinan-2-amine;hydrate
Molecular FormulaC7H17Cl2N2O3P
Molecular Weight279.10
Topological Polar Surface Area42.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Heavy Atom Count15
Formal Charge0
Complexity212
SMILES
C1CNP(=O)(OC1)N(CCCl)CCCl.O
InChI
InChI=1S/C7H15Cl2N2O2P.H2O/c8-2-5-11(6-3-9)14(12)10-4-1-7-13-14;/h1-7H2,(H,10,12);1H2
InChIKey
PWOQRKCAHTVFLB-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Cyclophosphamide Monohydrate
CAS: 6055-19-2
CID: 22420
Formula: C7H17Cl2N2O3P
MW: 279.10
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight279.10
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count5
Exact Mass278.0353848
Monoisotopic Mass278.0353848
Topological Polar Surface Area42.6 Ų
Heavy Atom Count15
Formal Charge0
Complexity212
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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