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Hydroxy Camptothecine

CAT: 0013-GTR19161139-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161139-01Size:100 mg
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Description
An alkaloid isolated from the stem wood of the Chinese tree, Camptotheca acuminata. This compound selectively inhibits the nuclear enzyme DNA topoisomerase, type I. Several semisynthetic analogs of camptothecin have demonstrated antitumor activity. (In Vitro) : (±) -10-Hydroxycamptothecin (10-OH-camptothecin) is an inhibitor of topo I. (±) -10-Hydroxycamptothecin (10-HCPT, 5-20 nM) markedly inhibits the proliferation of Colo 205 cells in a dose-dependent manner. (±) -10-Hydroxycamptothecin (5-20 nM) arrests Colo 205 cells in the G2 phase of the cell cycle and triggers apoptosis through a caspase-3-dependent pathway. (±) -10-Hydroxycamptothecin (HPT, 0.01-10 μg/mL) causes cell shrinage, nuclear fragmentation and condensed chromosomes and induces apoptosis of human urinary bladder cancer cell line (T24) . (In Vivo) : (±) -10-Hydroxycamptothecin (10-HCPT, 2.5-7.5 mg/kg/2 days, p.o.) significantly suppresss tumor growth in mouse xenografts. (±) -10-Hydroxycamptothecin (1-7.5 mg/kg, p.o., once per 2 or 4 days) causes no obvious acute toxicity in nude mice.
CAS Number
64439-81-2
Purity
>98% (HPLC)
Solubility
Soluble in DMSO
Smiles
CCC1 (C2=C (COC1=O) C (=O) N3CC4=C (C3=C2) N=C5C=CC (=CC5=C4) O) O
Molecular Formula
C20H16N2O5
Molecular Weight
364.35
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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