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Nicorandil

CAT: 0013-GTR19161110-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161110-01Size:500 mg
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Description
Nicorandil (Ikorel) is potassium channel activator. It acts by relaxing the smooth muscle of the blood vessels, especially those of the venous system. It does this through two methods. Firstly, by activating potassium channels, and secondly by donating nitric oxide to activate the enzyme guanylate cyclase. Guanylate cyclase causes activation of cGMP leading to both arterial and venous vasodilatation by de-phosphorylation of the myosin light chain. (In Vitro) :Nicorandil (SG-75) activates ATP-sensitive K+ channels composed of Kir6.2 and either sulfonylurea receptor (SUR) 2A or 2B.Nicorandil is a vasodilatory drug used to treat angina. Nicorandil (SG-75) stimulates guanylate cyclase to increase formation of cyclic GMP (cGMP) . cGMP activates protein kinase G (PKG) which phosphorylates and inhibits GTPase RhoA and decreases Rho-kinase activity. Reduced Rho-kinase activity permits an increase in myosin phosphatase activity, decreasing the calcium sensitivity of the smooth muscle. PKG also activates the sarcolemma calcium pump to remove activating calcium. PKG acts on K+ channels to promote K+ efflux and the ensuing hyperpolarization inhibits voltage-gated calcium channels. Overall, this leads to relaxation of the smooth muscle and coronary vasodilation.
CAS Number
65141-46-0
Product Name Alternative
2-Nicotinamidoethyl nitrate | SG-75
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 42 mg/mL (198.89 mM) ; Water: 17 mg/mL (80.5 mM) ; DMSO: 42 mg/mL (198.89 mM)
Smiles
O=[N+] ([O-]) OCCNC (C1=CN=CC=C1) =O
Molecular Formula
C8H9N3O4
Molecular Weight
211.18
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2-Nicotinamidoethyl nitrate

Alternative Products

CatalogName
B2197-5.1Nicorandil

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