Cefotiam hydrochloride

Cefotiam hydrochloride is a second-generation cephalosporin antibiotic, has broad-spectrum activity against Gram-positive and Gram-negative bacteria, its bactericidal activity results from the inhibition of cell wall synthesis via affinity for penicillin-binding proteins. (In Vitro) :Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has antibacterial activity with a MIC value of 1.56 μg/mL for P. mirabilis IFO 3849.Cefotiam (SCE-963; 0-6.25 μg/mL; 8 h) hydrochloride has highly active against both Staph. aureus (27 strains, MIC values of 0.5-1 μg/mL) and Staph. albus (8 strains, MICs 0.25-0.5 μg/mL) . All 29 strains of haemolytic streptococci, 9 strains of pneumococci and 6 strains of Streptococcus viridans with the MIC values of in the range 0.06-4 μg/mL. (In Vivo) :Cefotiam (SCE-963; 12.5-800 mg/kg; i.h.; twice a day for 5 d) hydrochloride can cure urinary tract infection with P. mirabilis in mice to reduce or complete eradicate bacteria in the bladder walls and kidneys.

66309-69-1

Cefotiam Hydrochloride | Halospor | Pansporin | Cefotiam dihydrochloride | Hydrochloride, Cefotiam | SCE 963

Pharmacology & Drug Discovery

>98% (HPLC)

Water: 10 mM

CN (C) CCN1C (=NN=N1) SCC2=C (N3[C@@H] ([C@@H] (C3=O) NC (=O) CC4=CSC (=N4) N) SC2) C (=O) O.Cl.Cl

C18H23N9O4S3·HCl

562.08

Storage temperature: -20°C. Stability: ≥ 2 years

For research use only.