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CAT: 0013-GTR19161055-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19161055-01Size:1 g
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Description
A cell-permeable derivative of 6-bromoindirubin that displays selective inhibition of GSK-3 with IC50 of 5 nM; also inhibit CDK1/Cyclin B and CDK5/p25 (IC50, 320 nM and 83 nM) ; maintains the undifferentiated phenotype in HESCs and MESCs, sustains the expression of Oct-3/4, Rex-1 and Nanog; promotes proliferation in mammalian cardiomyocytes.
CAS Number
667463-62-9
Product Name Alternative
6BIO | 6-BIO | GSK 3 IX | GSK 3 Inhibitor IX | MLS 2052 | MLS2052
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 23 mg/mL
Smiles
O=C (/C1=C2NC3=C (C\2=N/O) C=CC=C3) NC4=C1C=CC (Br) =C4
Molecular Formula
C16H10BrN3O2
Molecular Weight
356.1735
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2H-Indol-2-one, 6-bromo-3-[ (3E) -1,3-dihydro-3- (hydroxyimino) -2H-indol-2-ylidene]-1,3-dihydro-, (3Z) -

Chemical Information

6-Bromoindirubin-3'-oxime

6-bromoindirubin-3'-oxime is a member of the class of biindoles that is indirubin substituted at position 6 by a bromo group and in which the keto group at position 3' has undergone condensation with hydroxylamine to form the corresponding oxime. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor and an EC 2.7.11.26 (tau-protein kinase) inhibitor. It is a ketoxime, an organobromine compound, a member of oxindoles and a biindole.

CAS Number667463-62-9
PubChem CID448949
IUPAC Name6-bromo-3-(3-nitroso-1H-indol-2-yl)-1H-indol-2-ol
Molecular FormulaC16H10BrN3O2
Molecular Weight356.17
XLogP3.9
Topological Polar Surface Area81.2
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Heavy Atom Count22
Formal Charge0
Complexity438
SMILES
C1=CC=C2C(=C1)C(=C(N2)C3=C(NC4=C3C=CC(=C4)Br)O)N=O
InChI
InChI=1S/C16H10BrN3O2/c17-8-5-6-9-12(7-8)19-16(21)13(9)15-14(20-22)10-3-1-2-4-11(10)18-15/h1-7,18-19,21H
InChIKey
SAQUSDSPQYQNBG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 6-Bromoindirubin-3'-oxime
CAS: 667463-62-9
CID: 448949
Formula: C16H10BrN3O2
MW: 356.17
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight356.17
XLogP33.9
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count3
Rotatable Bond Count1
Exact Mass354.99564
Monoisotopic Mass354.99564
Topological Polar Surface Area81.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity438
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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