Products for Research Use Only

FR 180204

CAT: 0013-GTR19160972-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160972-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
FR 180204 is a potent, selective, ATP-competitive ERK inhibitor with Ki of 0.31 and 0.14 uM for ERK1 and ERK2, respectively; inhibits TGFβ-induced luciferase-expression in mink lung epithelial Mv1Lu cells, decreases plasma anti-CII antibody levels and attenuates delayed-type hypersensitivity in CII-immunized DBA/1 mice, also inhibits in vitro CII-induced proliferation of lymph node cells prepared from CII-immunized mice; enhances apoptotic and anti-proliferative effects of Akt inhibitor API-1 in human DLD-1 and LoVo colorectal cancer cells.
CAS Number
865362-74-9
Product Name Alternative
FR180204 | FR-180204
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 50 mg/mL
Smiles
NC1=NNC2=NN=C (C3=C4C=CC=CN4N=C3C5=CC=CC=C5) C=C21
Molecular Formula
C18H13N7
Molecular Weight
327.3427
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1H-Pyrazolo[3,4-c]pyridazin-3-amine, 5- (2-phenylpyrazolo[1,5-a]pyridin-3-yl) -