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Carfilzomib

CAT: 0013-GTR19160960-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160960-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, highly selective inhibitor chymotrypsin-like activity of proteasome with IC50 of 6 nM; weakly inhibits caspase-like and trypsin-like activities in cellular assays (IC50150-200 nM), also inhibits the chymotrypsin-like activity of the immunoproteasome (IC50=33 nM) ; accumulates proteasome substrates and induces cell cycle arrest and/or apoptosis; shows antitumor efficacy in vivo.Blood Cancer Approved.
CAS Number
868540-17-4
Product Name Alternative
PR 171 | PR171 | PR-171
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC (C) C[C@H] (NC ([C@@H] (NC (CN1CCOCC1) =O) CCC2=CC=CC=C2) =O) C (N[C@@H] (CC3=CC=CC=C3) C (N[C@@H] (CC (C) C) C ([C@]4 (C) OC4) =O) =O) =O.
Molecular Formula
C40H57N5O7
Molecular Weight
719.9099
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
L-Phenylalaninamide, (αS) -α-[[2- (4-morpholinyl) acetyl]amino]benzenebutanoyl-L-leucyl-N-[ (1S) -3-methyl-1-[[ (2R) -2-methyl-2-oxiranyl]carbonyl]butyl]-

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