Carfilzomib

• UNSPSC Description:

  Carfilzomib (PR-171) is an irreversible proteasome inhibitor with an IC50 of 5 nM in ANBL-6 and RPMI 8226 cells.

• Target Antigen:

  Apoptosis; Autophagy; Proteasome

• Type:

  Reference compound

• Related Pathways:

  Apoptosis;Autophagy;Metabolic Enzyme/Protease

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Carfilzomib.html

• Purity:

  99.98

• Solubility:

  DMSO : 125 mg/mL (ultrasonic)

• Smiles:

  C[C@@]1(C([C@H](CC(C)C)NC([C@@H](NC([C@H](CC(C)C)NC([C@@H](NC(CN2CCOCC2)=O)CCC3=CC=CC=C3)=O)=O)CC4=CC=CC=C4)=O)=O)OC1

• Molecular Weight:

  719.91

• References & Citations:

  [1]Kawada T, Iwai K. In vivo and in vitro metabolism of dihydrocapsaicin, a pungent principle of hot pepper [Capsicum annuum], in rats[J]. Agricultural and Biological Chemistry (Japan), 1985, 49(2).

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  Launched

• CAS Number:

  868540-17-4