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Ro-3306

CAT: 0013-GTR19160941-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160941-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Ro-3306 is a potent, selective, ATP-competitive CDK1 inhibitor with Ki of 35 nM against CDK1/cyclin B1, 10-fold selectivity relative to CDK2/cyclin E and >50-fold relative to CDK4/cyclin D; also inhibits CDK1/cyclin A complexes with Ki of 110 nM, shows >15-fold selectivity against a diverse panel of 8 human kinases; reversibly arrests human cells at the G (2) /M border of the cell cycle and allows for effective cell synchronization in early mitosis; enhances p53-mediated Bax activation and mitochondrial apoptosis in AML.
CAS Number
872573-93-8
Product Name Alternative
Ro3306
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 47 mg/mL
Smiles
O=C1N=C (NCC2=CC=CS2) S/C1=C/C3=CC=C4N=CC=CC4=C3
Molecular Formula
C18H13N3OS2
Molecular Weight
351.4453
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4 (5H) -Thiazolone, 5- (6-quinolinylmethylene) -2-[ (2-thienylmethyl) amino]-, (5Z) -

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406182RO-3306
256484-01Ro 3306

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