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RO-275

CAT: 0013-GTR19234683-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19234683-01Size:1 mg
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Description
RO-275 is an orally active, selective HCN1 inhibitor that also targets HCN2, HCN3, and HCN4 channels. It has demonstrated efficacy in improving working memory in preclinical models, making it a valuable research tool for studying cognitive disorders in both in vitro and in vivo experimental settings.
CAS Number
2648837-04-9
Product Name Alternative
RO275
Field of Research
Pharmacology & Drug Discovery
Purity
98.12% (May vary between batches)
Solubility
DMSO:4 mg/mL (11.37 mM)
Smiles
O=C (N) C1=NC (C#CC=2C=CN=C (Cl) C2C) =C (N1C=3C=NC=CC3) C
Molecular Formula
C18H14ClN5O
Molecular Weight
351.79
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

4-[2-(2-Chloro-3-methyl-4-pyridinyl)ethynyl]-5-methyl-1-pyridin-3-ylimidazole-2-carboxamide
CAS Number2648837-04-9
PubChem CID156441547
IUPAC Name4-[2-(2-chloro-3-methyl-4-pyridinyl)ethynyl]-5-methyl-1-pyridin-3-ylimidazole-2-carboxamide
Molecular FormulaC18H14ClN5O
Molecular Weight351.8
XLogP2.5
Topological Polar Surface Area86.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity558
SMILES
CC1=C(C=CN=C1Cl)C#CC2=C(N(C(=N2)C(=O)N)C3=CN=CC=C3)C
InChI
InChI=1S/C18H14ClN5O/c1-11-13(7-9-22-16(11)19)5-6-15-12(2)24(18(23-15)17(20)25)14-4-3-8-21-10-14/h3-4,7-10H,1-2H3,(H2,20,25)
InChIKey
STQKUEFQEVDNLU-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-[2-(2-Chloro-3-methyl-4-pyridinyl)ethynyl]-5-methyl-1-pyridin-3-ylimidazole-2-carboxamide
CAS: 2648837-04-9
CID: 156441547
Formula: C18H14ClN5O
MW: 351.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight351.8
XLogP32.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count4
Exact Mass351.0886878
Monoisotopic Mass351.0886878
Topological Polar Surface Area86.7 Ų
Heavy Atom Count25
Formal Charge0
Complexity558
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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