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TW-37

CAT: 0013-GTR19160920-05Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160920-05Size:5 mg
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Description
TW-37 is a potent, nonpeptidic small-molecule inhibitor of Bcl-2 with Ki of 290 nM, also binds to Bcl-xL and Mcl-1 with high affinities; potently inhibits cell growth in PC-3 prostate cancer cells with an IC (50) value of 200 nM and effectively induces apoptosis in a dose-dependent manner; shows antiangiogenic effect against endothelial cells (IC50=1.8 uM) with no cytotoxic effects for fibroblasts, induces endothelial cell apoptosis by mitochondrial depolarization and activation of caspase-9 and caspase-3, decreases the density of functional human microvessels in mouse model of human angiogenesis.
CAS Number
877877-35-5
Product Name Alternative
TW 37 | TW37
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 42 mg/mL
Smiles
O=C (NC1=CC=C (S (=O) (C2=CC=CC=C2C (C) (C) C) =O) C=C1) C3=CC (CC4=CC=CC=C4C (C) C) =C (O) C (O) =C3O
Molecular Formula
C33H35NO6S
Molecular Weight
573.6991
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[4-[[2- (1,1-dimethylethyl) phenyl]sulfonyl]phenyl]-2,3,4-trihydroxy-5-[[2- (1-methylethyl) phenyl]methyl]-

Chemical Information

TW-37

TW-37 is a secondary carboxamide resulting from the formal condensation of the carboxy group of 2,3,4-trihydroxy-5-[2-(propan-2-yl)benzyl]benzoic acid with the amino group of 4-[(2-tert-butylphenyl)sulfonyl]aniline. It is a potent inhibitor of Bcl-2 family of proteins (Ki = 260, 290 and 1110 nM for Mcl-1, Bcl-2 and Bcl-xL). It has a role as a radiosensitizing agent, a B-cell lymphoma 2 inhibitor, an antineoplastic agent, an angiogenesis inhibitor and an apoptosis inducer. It is a secondary carboxamide, a member of benzamides, a benzenetriol and a sulfone.

CAS Number877877-35-5
PubChem CID11455910
IUPAC NameN-[4-(2-tert-butylphenyl)sulfonylphenyl]-2,3,4-trihydroxy-5-[(2-propan-2-ylphenyl)methyl]benzamide
Molecular FormulaC33H35NO6S
Molecular Weight573.7
XLogP7.8
Topological Polar Surface Area132
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Heavy Atom Count41
Formal Charge0
Complexity963
SMILES
CC(C)C1=CC=CC=C1CC2=CC(=C(C(=C2O)O)O)C(=O)NC3=CC=C(C=C3)S(=O)(=O)C4=CC=CC=C4C(C)(C)C
InChI
InChI=1S/C33H35NO6S/c1-20(2)25-11-7-6-10-21(25)18-22-19-26(30(36)31(37)29(22)35)32(38)34-23-14-16-24(17-15-23)41(39,40)28-13-9-8-12-27(28)33(3,4)5/h6-17,19-20,35-37H,18H2,1-5H3,(H,34,38)
InChIKey
PQAPVTKIEGUPRN-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of TW-37
CAS: 877877-35-5
CID: 11455910
Formula: C33H35NO6S
MW: 573.7
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight573.7
XLogP37.8
Hydrogen Bond Donor Count4
Hydrogen Bond Acceptor Count6
Rotatable Bond Count8
Exact Mass573.21850901
Monoisotopic Mass573.21850901
Topological Polar Surface Area132 Ų
Heavy Atom Count41
Formal Charge0
Complexity963
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
A4234-5.1TW-37
256983-01TW 37

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