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AZD-1480

CAT: 0013-GTR19160737-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160737-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
A potent, selective, ATP competitive JAK2 inhibitor with Ki of 0.26 nM; demonstrates significant JAK2 selectivity over JAK3 and marginal selectivity over JAK1; blocks STAT3 phosphorylation in a panel of human solid tumor cell lines, potently inhibits the growth of the TEL-Jak2 cell line (GI50=60 nM) ; suppresses the growth of human solid tumor xenografts harboring persistent Stat3 activity.Liver Cancer Phase 1 Discontinued.
CAS Number
935666-88-9
Product Name Alternative
AZD1480 | AZD 1480
Purity
>98% (HPLC)
Solubility
10 mM in DMSO
Smiles
CC1=CC (NC2=NC (N[C@H] (C3=NC=C (F) C=N3) C) =NC=C2Cl) =NN1
Molecular Formula
C14H14ClFN8
Molecular Weight
348.766
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2,4-Pyrimidinediamine, 5-chloro-N2-[ (1S) -1- (5-fluoro-2-pyrimidinyl) ethyl]-N4- (5-methyl-1H-pyrazol-3-yl) -

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