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Fluvastatin sodium salt

CAT: 0013-GTR19160719-01Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160719-01Size:500 mg
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Description
Fluvastatin sodium is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), used to treat hypercholesterolemia and to prevent cardiovascular disease. (In Vitro) :Fluvastatin sodium (XU 62320) is a competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase (HMGCR), the enzyme that catalyzes the conversion of HMG-CoA to mevalonic acid, the rate-limiting step in cholesterol biosynthesis. Human hepatocellular carcinoma cell (HCC) studies indicate that Fluvastatin induces G2/M phase arrest. In the presence of Fluvastatin (XU 62320), HCC cells show a decrease of Bcl-2 and procaspase-9 expression, and an increase in Bax, cleaved caspase-3, and cytochrome c. Fluvastatin (XU 62320) is antilipemic and is used to reduce plasma cholesterol levels and prevent cardiovascular disease.
CAS Number
93957-55-2
Product Name Alternative
Canef | Fluindostatin | Lescol XL | Lipaxan | Vastin | XU-62-320 | XU62320
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Water: 1 mg/mL (2.3 mM) ; DMSO: 87 mg/mL (200.71 mM)
Smiles
O=C ([O-]) C[C@@H] (O) C[C@@H] (O) /C=C/C (N1C (C) C) =C (C2=CC=C (F) C=C2) C3=C1C=CC=C3.[Na+]
Molecular Formula
C24H25FNNaO4
Molecular Weight
433.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sodium (3S,5R, E) -7- (3- (4-fluorophenyl) -1-isopropyl-1H-indol-2-yl) -3,5-dihydroxyhept-6-enoate

Chemical Information

Fluvastatin Sodium

(3S,5R)-fluvastatin sodium is an organic sodium salt resulting from the replacement of the proton from the carboxy group of (3S,5R)-fluvastatin by a sodium ion. It is an organic sodium salt and a statin (synthetic). It contains a (3S,5R)-fluvastatin(1-). It is an enantiomer of a (3R,5S)-fluvastatin sodium.

CAS Number93957-55-2
PubChem CID23679527
IUPAC Namesodium (E,3S,5R)-7-[3-(4-fluorophenyl)-1-propan-2-ylindol-2-yl]-3,5-dihydroxyhept-6-enoate
Molecular FormulaC24H25FNNaO4
Molecular Weight433.4
Topological Polar Surface Area85.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Heavy Atom Count31
Formal Charge0
Complexity596
SMILES
CC(C)N1C2=CC=CC=C2C(=C1/C=C/[C@@H](C[C@@H](CC(=O)[O-])O)O)C3=CC=C(C=C3)F.[Na+]
InChI
InChI=1S/C24H26FNO4.Na/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30;/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30);/q;+1/p-1/b12-11+;/t18-,19-;/m0./s1
InChIKey
ZGGHKIMDNBDHJB-RPQBTBOMSA-M
Chemical Structure
2D Structure
2D structure of Fluvastatin Sodium
CAS: 93957-55-2
CID: 23679527
Formula: C24H25FNNaO4
MW: 433.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight433.4
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count5
Rotatable Bond Count8
Exact Mass433.16653072
Monoisotopic Mass433.16653072
Topological Polar Surface Area85.5 Ų
Heavy Atom Count31
Formal Charge0
Complexity596
Isotope Atom Count0
Defined Atom Stereocenter Count2
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count1
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

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