Products for Research Use Only
RegisterLogin

Ezutromid

CAT: 0013-GTR19160688-02Size: 2 mgDry Ice: NoHazardous: No
Product image 1
1 / 1
CAT#:0013-GTR19160688-02Size:2 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Description
The first orally bioavailable small molecule utrophin upregulator; demonstrates significant disease modifying effects in DMD models; reduces a number of the pathological effects of dystrophin deficiency, results in reduced pathology, better muscle physiology leading to an increase in overall strength, and an ability to resist fatigue after forced exercise. (In Vitro) :Ezutromid induces increased levels of utrophin RNA in human muscle cells. Treatment of human DMD cells with Ezutromid lead to a 2-fold increase in utrophin protein levels at an optimal concentration of 0.3 uM after 3 days of treatment. Ezutromid was safe and well tolerated with plasma concentrations achieved suf cient to cause a 50% increase in concentrations of utrophin in cells. Ezutromid led to a 30% increase in Utrn mRNA level and resulted in a 2.0-fold increase in UTRN protein level. (In Vivo) :Note: You can dissolve the products in phosphate buffered saline (PBS), 0.1% Tween-20, 5% DMSO) .
CAS Number
945531-77-1
Product Name Alternative
SMT-C1100 | VOX-C1100 | BMN-195
Purity
>98% (HPLC)
Solubility
DMSO: 10 mg/mL
Smiles
O=S (C1=CC=C (OC (C2=CC=C3C=CC=CC3=C2) =N4) C4=C1) (CC) =O
Molecular Formula
C19H15NO3S
Molecular Weight
337.3923
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzoxazole, 5- (ethylsulfonyl) -2- (2-naphthalenyl) -

Chemical Information

5-(Ethylsulfonyl)-2-(2-naphthalenyl)benzoxazole

Ezutromid has been investigated for the treatment of Muscular Dystrophy, Duchenne.

CAS Number945531-77-1
PubChem CID25109292
IUPAC Name5-ethylsulfonyl-2-naphthalen-2-yl-1,3-benzoxazole
Molecular FormulaC19H15NO3S
Molecular Weight337.4
XLogP4.3
Topological Polar Surface Area68.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count24
Formal Charge0
Complexity543
SMILES
CCS(=O)(=O)C1=CC2=C(C=C1)OC(=N2)C3=CC4=CC=CC=C4C=C3
InChI
InChI=1S/C19H15NO3S/c1-2-24(21,22)16-9-10-18-17(12-16)20-19(23-18)15-8-7-13-5-3-4-6-14(13)11-15/h3-12H,2H2,1H3
InChIKey
KSGCNXAZROJSNW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 5-(Ethylsulfonyl)-2-(2-naphthalenyl)benzoxazole
CAS: 945531-77-1
CID: 25109292
Formula: C19H15NO3S
MW: 337.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight337.4
XLogP34.3
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass337.07726451
Monoisotopic Mass337.07726451
Topological Polar Surface Area68.6 Ų
Heavy Atom Count24
Formal Charge0
Complexity543
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
206444Ezutromid
A20897-100Ezutromid 100mg
A20897-25Ezutromid 25mg
A20897-200Ezutromid 200mg
A20897-5Ezutromid 5mg
A20897-2Ezutromid 2mg
A20897-10Ezutromid 10mg
HY-17614R-01Ezutromid (Standard)
A20897-50Ezutromid 50mg
A20897-10mM-DEzutromid 10mM * 1mL in DMSO

Popular Products