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Bithionol

CAT: 0013-GTR19160629-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160629-01Size:1 g
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Description
Bithionol, formerly marketed as an active ingredient in various topical drug products, was shown to be a potent photosensitizer with the potential to cause serious skin disorders. Approvals of the NDA’s for bithionol drug products were withdrawn on 1967. (In Vitro) :Bithionol (0.1-10 mg/mL, 72 h) shows toxicity to Neoparamoeba spp parasites in sea water.Bithionol (0-100 μM) inhibits adenylyl cyclase (AC) activity with an IC50 value of 4 μM.Bithionol (50 and 100 μM, 0-10 min) decreases in cAMP formation with essentially complete inhibition of sAC-dependent cAMP accumulation in sAC-overexpressing 4-4 cells. (In Vivo) :Bithionol (100 mg/kg/day, oral administration for 12 days) is moderately active against immature H. nana in mice.
CAS Number
97-18-7
Product Name Alternative
CP 3438 | NSC 9872 | NSC 47129
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO: 7 mg/mL; Water: 68 mg/mL
Smiles
ClC1=CC (Cl) =C (O) C (SC2=CC (Cl) =CC (Cl) =C2O) =C1
Molecular Formula
C12H6Cl4O2S
Molecular Weight
356.04
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6,6'-thiobis (2,4-dichlorophenol)

Alternative Products

CatalogName
B6131-50000Bithionol
MBS5752800Bithionol sulfoxide

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