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GSK620

CAT: 0013-GTR19166923-06Size: 50 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166923-06Size:50 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
GSK620 is a highly selective pan-BD2 BET inhibitor demonstrating potent anti-inflammatory activity in human whole blood assays. Its excellent selectivity profile and favorable oral pharmacokinetics support its use for in vivo research into inflammation and oncology, where BET bromodomain function is implicated.
CAS Number
2088410-46-0
Product Name Alternative
Anti-inflammatory, blood, human, GSK 620, GSK620, GSK-620, EpigeneticReaderDomain, Epigenetic Reader Domain, oral, pan-BD2, inhibit, Inhibitor, phenotype, whole, selectivity
Field of Research
Epigenetics & Chromatin
Purity
99.05% (May vary between batches)
Solubility
10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (10.14 mM) ; DMSO:45 mg/mL (138.31 mM)
Smiles
CNC (=O) c1cc (cn (Cc2ccccc2) c1=O) C (=O) NC1CC1
Molecular Formula
C18H19N3O3
Molecular Weight
325.36
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

1-Benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide
CAS Number2088410-46-0
PubChem CID126648559
IUPAC Name1-benzyl-5-N-cyclopropyl-3-N-methyl-2-oxopyridine-3,5-dicarboxamide
Molecular FormulaC18H19N3O3
Molecular Weight325.4
XLogP1.5
Topological Polar Surface Area78.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Heavy Atom Count24
Formal Charge0
Complexity599
SMILES
CNC(=O)C1=CC(=CN(C1=O)CC2=CC=CC=C2)C(=O)NC3CC3
InChI
InChI=1S/C18H19N3O3/c1-19-17(23)15-9-13(16(22)20-14-7-8-14)11-21(18(15)24)10-12-5-3-2-4-6-12/h2-6,9,11,14H,7-8,10H2,1H3,(H,19,23)(H,20,22)
InChIKey
QZZCUOVXHPAQRQ-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-Benzyl-N5-cyclopropyl-N3-methyl-2-oxo-1,2-dihydropyridine-3,5-dicarboxamide
CAS: 2088410-46-0
CID: 126648559
Formula: C18H19N3O3
MW: 325.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight325.4
XLogP31.5
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count5
Exact Mass325.14264148
Monoisotopic Mass325.14264148
Topological Polar Surface Area78.5 Ų
Heavy Atom Count24
Formal Charge0
Complexity599
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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Alternative Products

CatalogName
BA4681-100GSK620
A22521-100GSK620 100mg
A22521-25GSK620 25mg
A22521-50GSK620 50mg
A22521-1GSK620 1mg
A22521-5GSK620 5mg
A22521-500GSK620 500mg
A22521-10GSK620 10mg
A22521-10mM-DGSK620 10mM * 1mL in DMSO

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