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R1487

CAT: 0013-GTR19166405-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19166405-02Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
R1487 is a potent and selective small molecule inhibitor targeting the p38α MAP kinase with oral bioavailability. It is a valuable research tool for investigating inflammatory and stress response pathways in both cellular and animal models of disease.
CAS Number
449811-92-1
Product Name Alternative
P38MAPK, p38α, p38 MAPK, R1487, R-1487, R 1487
Field of Research
Signal Transduction
Purity
≥95% (May vary between batches)
Solubility
DMSO:Slightly soluble
Smiles
Cn1c2nc (NC3CCOCC3) ncc2cc (Oc2ccc (F) cc2F) c1=O
Molecular Formula
C19H18F2N4O3
Molecular Weight
388.37
Storage Conditions
-20°C
Notes
For research use only.

Chemical Information

R-1487
CAS Number449811-92-1
PubChem CID11406590
IUPAC Name6-(2,4-difluorophenoxy)-8-methyl-2-(oxan-4-ylamino)pyrido[2,3-d]pyrimidin-7-one
Molecular FormulaC19H18F2N4O3
Molecular Weight388.4
XLogP2.8
Topological Polar Surface Area76.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Heavy Atom Count28
Formal Charge0
Complexity602
SMILES
CN1C2=NC(=NC=C2C=C(C1=O)OC3=C(C=C(C=C3)F)F)NC4CCOCC4
InChI
InChI=1S/C19H18F2N4O3/c1-25-17-11(10-22-19(24-17)23-13-4-6-27-7-5-13)8-16(18(25)26)28-15-3-2-12(20)9-14(15)21/h2-3,8-10,13H,4-7H2,1H3,(H,22,23,24)
InChIKey
KKKRKRMVJRHDMG-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of R-1487
CAS: 449811-92-1
CID: 11406590
Formula: C19H18F2N4O3
MW: 388.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight388.4
XLogP32.8
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count8
Rotatable Bond Count4
Exact Mass388.13469677
Monoisotopic Mass388.13469677
Topological Polar Surface Area76.6 Ų
Heavy Atom Count28
Formal Charge0
Complexity602
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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CatalogName
C07243R1487
MBS3610665-01R1487 (Hydrochloride)
BISN0265R1487 Hydrochloride
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A21231-25R1487 Hydrochloride 25mg
A21231-5R1487 Hydrochloride 5mg
A21231-50R1487 Hydrochloride 50mg
A21231-2R1487 Hydrochloride 2mg
A21231-100R1487 Hydrochloride 100mg
A21231-10R1487 Hydrochloride 10mg

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