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NLG919

CAT: 0013-GTR19163306-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19163306-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NLG919 is a potent IDO (indoleamine- (2,3) -dioxygenase) pathway inhibitor with Ki/EC50 of 7 nM/75 nM in cell-free assays. Phase 1. (In Vitro) :IDO-IN-7 (NLG-919 analogue) is a potent IDO1 inhibitor (IC50=38 nM) . The binding mode of IDO-IN-7 to IDO1 is experimentally available and shows a direct coordinative interaction to the sixth coordination site of ferric heme. IDO-IN-7 has been used as reference compound in other studies to validate high-throughput screening assay for IDO1 inhibition and develop immunostimulatory nanomicellar carrier.
CAS Number
1402836-58-1
Product Name Alternative
GDC-0919
Purity
>98% (HPLC)
Solubility
Ethanol: 56 mg/mL warmed (198.31 mM) ; DMSO: 15 mg/mL warmed (53.11 mM)
Smiles
OC (C1CCCCC1) CC (C2=C3C=CC=C2) N4C3=CN=C4
Molecular Formula
C18H22N2O
Molecular Weight
282.38
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1-cyclohexyl-2- (5H-imidazo[5,1-a]isoindol-5-yl) ethanol

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