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Rafoxanide

CAT: 0013-GTR19162868-02Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19162868-02Size:1 g
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Description
A salicylanilide anthelmintic agent that also shows to be an allosteric inhibitor of SPAK and OSR1; has antiangiogenic activity in zebrafish with IC50 of 1.69 uM on the intersegmental vessels and 1.45 uM on the subintestinal vessels.Parasite Infection Approved.
CAS Number
22662-39-1
Product Name Alternative
Rafoxanide | BRN 2228187 | Disalan | Duofas | EINECS 245-148-9
Purity
>98% (HPLC)
Solubility
DMSO: ≥ 31 mg/mL
Smiles
C1=CC (=CC=C1OC2=C (C=C (C=C2) NC (=O) C3=C (C (=CC (=C3) I) I) O) Cl) Cl
Molecular Formula
C19H11Cl2I2NO3
Molecular Weight
626.0105
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Benzamide, N-[3-chloro-4- (4-chlorophenoxy) phenyl]-2-hydroxy-3,5-diiodo-

Chemical Information

Rafoxanide

Rafoxanide is a salicylanilide resulting from the formal condensation of the carboxy group of 2-hydroxy-3,5-diiodobenzoic acid with the amino group of 3-chloro-4-(4-chlorophenoxy)aniline. It is a broad-spectrum anthelmintic used for the treatment of parasitic infections in cattle and sheep. It has a role as an autophagy inducer, a chemosensitiser, an antibacterial agent, an anthelminthic drug, an antineoplastic agent, an antifungal agent, a DNA synthesis inhibitor, a B-Raf inhibitor and an EC 2.7.11.22 (cyclin-dependent kinase) inhibitor. It is a secondary carboxamide, a member of benzamides, a member of phenols, an aromatic ether, an organoiodine compound, a member of salicylanilides and a member of monochlorobenzenes.

CAS Number22662-39-1
PubChem CID31475
IUPAC NameN-[3-chloro-4-(4-chlorophenoxy)phenyl]-2-hydroxy-3,5-diiodobenzamide
Molecular FormulaC19H11Cl2I2NO3
Molecular Weight626.0
XLogP7
Topological Polar Surface Area58.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity507
SMILES
C1=CC(=CC=C1OC2=C(C=C(C=C2)NC(=O)C3=C(C(=CC(=C3)I)I)O)Cl)Cl
InChI
InChI=1S/C19H11Cl2I2NO3/c20-10-1-4-13(5-2-10)27-17-6-3-12(9-15(17)21)24-19(26)14-7-11(22)8-16(23)18(14)25/h1-9,25H,(H,24,26)
InChIKey
NEMNPWINWMHUMR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Rafoxanide
CAS: 22662-39-1
CID: 31475
Formula: C19H11Cl2I2NO3
MW: 626.0
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight626.0
XLogP37
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count3
Rotatable Bond Count4
Exact Mass624.82054
Monoisotopic Mass624.82054
Topological Polar Surface Area58.6 Ų
Heavy Atom Count27
Formal Charge0
Complexity507
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA2067-1000Rafoxanide
HY-17598S-01Rafoxanide-13C6
HY-17598R-01Rafoxanide (Standard)
MBS5799351Rafoxanide 13C6

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