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Doxofylline

CAT: 0013-GTR19161715-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19161715-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Doxofylline is a phosphodiesterase inhibitor and a xanthine derivative drug for asthma. (In Vitro) :Doxofylline (5, 10 μM; 48 h) shows potent protection against LPS-induced epithelial inflammation by reducing PGE2, NO release, and decreasing mitochondrial ROS generation in 16HBE cells.Doxofylline (5, 10 μM; 48 h) suppresses LPS-induced expression of NADPH oxidase subunits and TXNIP 16HBE cells.Doxofylline (5, 10 μM; 48 h) inhibits LPS-induced NLRP3 inflammasome activation and secretion of IL-1b and IL-18, as well as mitigates LPS-mediated SIRT1 reduction.Doxofylline (0.1-10 μM; 15 min) significantly reduces fMLP-induced leukocyte migration in BM cells (fMLP: Formyl-Methionyl-Leucyl-Phenylalanine) . (In Vivo) :Doxofylline (0.3, 1 mg/kg; i.p.; single) inhibits LPS-induced inflammation in the lungs of mice.Doxofylline (0.3 mg/kg; i.p.; pre-treat; single) notably reduces the adhesion of cells to the vascular tissue and surpresses the expression of LPS-induced ICAM-1 in vivo.
CAS Number
69975-86-6
Product Name Alternative
Doxofylline | Ansimar | ABC-12-3 | ABC-1213 | ABC 1213 | ALT 07 | DO 309
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 2 mg/mL (7.51 mM) ; Water: 24 mg/mL (90.14 mM) ; DMSO: 53 mg/mL (199.06 mM)
Smiles
O=C (N1C) N (C) C2=C (N (CC3OCCO3) C=N2) C1=O
Molecular Formula
C11H14N4O4
Molecular Weight
266.26
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
7- ((1,3-dioxolan-2-yl) methyl) -1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Alternative Products

CatalogName
B1734-5.1Doxofylline
HY-B0004S1-01Doxofylline-d4
HY-B0004R-01Doxofylline (Standard)
CS-O-16914Doxofylline-d6

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