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Artesunate

CAT: 0013-GTR19160900-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160900-01Size:200 mg
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Description
Artesunate is a part of the artemisinin group of agents with an IC50 of 90% efficacious at reducing egg production in Schistosoma haematobium infection. (In Vitro) :Artesunate is an inhibitor of both STAT-3 and exported protein 1 (EXP1) . Artesunate treatment for 24 h causes a significant increase in the levels of reactive oxygen species (ROS) in a dose-dependent manner in both cell lines. Moreover, Western blotting shows that the levels ofγ-H2AX are significantly elevated when cancer cells are treated with Artesunate in the higher dose range for 24 h. Artesunate also shows a time-dependent effect on the level of RAD51 in A2780 and HO8910 cells. In two types of non-malignant cells, normal human fibroblasts and immortalized epithelial cells, FTE-187, the level of RAD51 is not altered by Artesunate. In A2780 cells, the level of RAD51 mRNA is indeed decreased by the addition of Artesunate, in a dose-dependent manner. Correspondingly, the promoter activity of RAD51 is significantly inhibited by Artesunate. In contrast, the RAD51 mRNA level in H8910 cells is not affected by Artesunate. (In Vivo) :Tumor growth is significantly reduced in the group receiving combined treatment of Artesunate and cisplatin (P<0.01) . In comparison, Artesunate alone has no significant effect on the growth of tumor xenografts for both cell lines.
CAS Number
88495-63-0
Product Name Alternative
Artesunic Acid | NSC 712571 | WR 256283
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
Ethanol: 77 mg/mL (200.3 mM) ; DMSO: 77 mg/mL (200.3 mM)
Smiles
C[C@@H]1CC[C@H]2[C@@H] (C) [C@H] (OC (CCC (O) =O) =O) O[C@H]3[C@@]24[C@H]1CC[C@] (OO4) (C) O3
Molecular Formula
C19H28O8
Molecular Weight
384.42
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
4-oxo-4- (((3R,5aS,6R,8aS,9R,10S,12R,12aR) -3,6,9-trimethyldecahydro-12H-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl) oxy) butanoic acid

Alternative Products

CatalogName
B3662-10Artesunate

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