Tris(3-hydroxypropyltriazolylmethyl)amine

Tris(3-hydroxypropyltriazolylmethyl)amine

• CAS Number: 760952-88-3
• UNSPSC Description: Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is an accelerating ligand in the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) and protects cells from oxidants generated by copper-catalyzed reduction of oxygen by ascorbate. In addition, Tris(3-hydroxypropyltriazolylmethyl)amine can also protect the histidine moiety of biomolecules in a manner proportional to the ligand concentration[1][2][3][4][5].
• Target Antigen: Biochemical Assay Reagents
• Type: Biochemical Assay Reagents
• Related Pathways: Others
• Field of Research: Others
• Assay Protocol: https://www.medchemexpress.com/tris-3-hydroxypropyltriazolylmethyl-amine.html
• Purity: 99.54
• Solubility: DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 175 mg/mL
• Smiles: OCCCN1N=NC(CN(CC2=CN(CCCO)N=N2)CC3=CN(CCCO)N=N3)=C1
• Molecular Weight: 434.50
• References & Citations: [1]Hong V, et al. Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation. Angew Chem Int Ed Engl. 2009;48(52):9879-83.|[2]Hong V, et al. Labeling live cells by copper-catalyzed alkyne− azide click chemistry. Bioconjugate chemistry 21.10 (2010): 1912-1916.|[3]Rathinam S, et al. Conjugation of CRAMP18-35 Peptide to Chitosan and Hydroxypropyl Chitosan via Copper-Catalyzed Azide-Alkyne Cycloaddition and Investigation of Antibacterial Activity. Int J Mol Sci. 2024 Aug 30;25(17):9440.|[4]Yuan Y, et al. Bioorthogonal Turn-On Probe Based on Aggregation-Induced Emission Characteristics for Cancer Cell Imaging and Ablation. Angew Chem Int Ed Engl. 2016 May 23;55(22):6457-61.|[5]Kozarski M, et al. Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs. RSC Adv. 2023 Apr 25;13(19):12809-12824.
• Shipping Conditions: Room Temperature
• Storage Conditions: -20°C, 3 years; 4°C, 2 years (Powder)
• Clinical Information: No Development Reported