Tris(3-hydroxypropyltriazolylmethyl)amine

• UNSPSC Description:

  Tris(3-hydroxypropyltriazolylmethyl)amine (THPTA) is an accelerating ligand in the copper-catalyzed azide-alkyne cycloaddition reaction (CuAAC) and protects cells from oxidants generated by copper-catalyzed reduction of oxygen by ascorbate. In addition, Tris(3-hydroxypropyltriazolylmethyl)amine can also protect the histidine moiety of biomolecules in a manner proportional to the ligand concentration[1][2][3][4][5].

• Target Antigen:

  Biochemical Assay Reagents

• Type:

  Biochemical Assay Reagents

• Related Pathways:

  Others

• Field of Research:

  Others

• Assay Protocol:

  https://www.medchemexpress.com/tris-3-hydroxypropyltriazolylmethyl-amine.html

• Purity:

  99.54

• Solubility:

  DMSO : 100 mg/mL (ultrasonic)|H2O : ≥ 175 mg/mL

• Smiles:

  OCCCN1N=NC(CN(CC2=CN(CCCO)N=N2)CC3=CN(CCCO)N=N3)=C1

• Molecular Weight:

  434.50

• References & Citations:

  [1]Hong V, et al. Analysis and optimization of copper-catalyzed azide-alkyne cycloaddition for bioconjugation. Angew Chem Int Ed Engl. 2009;48(52):9879-83.|[2]Hong V, et al. Labeling live cells by copper-catalyzed alkyne− azide click chemistry. Bioconjugate chemistry 21.10 (2010): 1912-1916.|[3]Rathinam S, et al. Conjugation of CRAMP18-35 Peptide to Chitosan and Hydroxypropyl Chitosan via Copper-Catalyzed Azide-Alkyne Cycloaddition and Investigation of Antibacterial Activity. Int J Mol Sci. 2024 Aug 30;25(17):9440.|[4]Yuan Y, et al. Bioorthogonal Turn-On Probe Based on Aggregation-Induced Emission Characteristics for Cancer Cell Imaging and Ablation. Angew Chem Int Ed Engl. 2016 May 23;55(22):6457-61.|[5]Kozarski M, et al. Towards superior mRNA caps accessible by click chemistry: synthesis and translational properties of triazole-bearing oligonucleotide cap analogs. RSC Adv. 2023 Apr 25;13(19):12809-12824.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Clinical Information:

  No Development Reported

• CAS Number:

  760952-88-3