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CD437

CAT: 0013-GTR19160902-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160902-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CD437 is a synthetic retinoid that is an RARγ-selective agonist. It displays RARγ-dependent and -independent effects on differentiation and apoptosis. CD437 induces apoptosis and acts synergistically with TRAIL receptor-2 agonist in malignant melanoma. CD437 inhibits DNA replication in cells and recombinant POLA1 activity in vitro. (In Vitro) :CD437 is a selective RARγ agonist. Growth inhibition by CD437 in these lung cancer cell lines is apparent after 2 days of treatment with 10 μM CD437. Dose-response experiments demonstrate that CD437 reduces the numbers of H460, SK-MES-1, A549, and H292 cells with 50% inhibitory values of approximately 0.5, 0.4, 3, and 0.85 μM, respectively. Treatment for 72 h with CD437 causes a strong dose-dependent growth inhibition in all melanoma cell lines. At a concentration of 5 μM CD437, only about 5 to 25% of the cells remain viable after 3 d. The concentrations of CD437 required for 50% growth inhibition (IC50) range from 10 μM for MeWo to 0.1 μM for SK-Mel-23 showing the highest sensitivity. (In Vivo) :Tumors in CD437-treated mice stop growing, an effect that becomes already statistically significant (P<0.01) at day 13, 3 d after first administration of CD437, and is maintained for more than 3 wk after discontinuation of treatment. Further histologic analysis demonstrates marked c-fos mRNA levels at the tumor-stroma edge in CD437-treated tumors.
CAS Number
125316-60-1
Product Name Alternative
CD437 | CD 437 | CD-437 | Ro-472077
Field of Research
Immunology & Inflammation
Purity
>98% (HPLC)
Solubility
DMSO : 150 mg/mL. 376.42 mM
Smiles
O=C (C1=CC=C2C=C (C3=CC=C (O) C (C4 (C5) CC6CC5CC (C6) C4) =C3) C=CC2=C1) O
Molecular Formula
C27H26O3
Molecular Weight
398.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
6-[3- (1-adamantyl) -4-hydroxyphenyl]naphthalene-2-carboxylic acid

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2636-5CD437
HY-100532S-01CD437-13C6
C08635-5mgCD437 (AHPN)
HY-100532R-01CD437 (Standard)
366872-01CD 437 (AHPN, CD437, O-Desmethyl Adapalene, 6- (4-Hydroxy-3-tricyclo[3.3.1.13,7]dec-1-ylphenyl) -2-naphthalenecarboxylic Acid)

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