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JNK-IN-7

CAT: 0013-GTR19160539-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160539-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
JNK-IN-7 is a relatively selective JNKs inhibitor (IC50= 1.54/1.99/0.75 for JNK1/2/3) ; also bound to IRAK1, PIK3C3, PIP5K3 and PIP4K2C. (In Vitro) :JNK-IN-7 is a relatively selective JNK inhibitor in cells. In addition to JNK 1, 2, 3, JNK-IN-7 also binds to IRAK1 (IC50=14.1 nM), YSK4 (IC50=4.8 nM), ERK3 (IC50=22 nM), PIK3C3, PIP5K3 and PIP4K2C. Expression of divalent metal-ion transporter 1 (DMT1) in HCT116 is demonstrated to be markedly decreased under stimulation with TNF for 24 and 48 h, while JNK-IN-7 can significantly reverse the decrease. TNF can down-regulate DMT1 expression, while JNK-IN-7 can markedly suppress this function.
CAS Number
1408064-71-0
Product Name Alternative
JNK-IN-7 | JNK inhibitor | JNKIN7 | JNK IN 7
Field of Research
Signal Transduction
Purity
>98% (HPLC)
Solubility
DMSO : 33.33 mg/mL. 67.53 mM; H2O : < 0.1 mg/mL
Smiles
C (=O) (Nc1cccc (c1) C (=O) Nc1ccc (cc1) Nc1nccc (n1) c1cnccc1) /C=C/CN (C) C
Molecular Formula
C28H27N7O2
Molecular Weight
493.56
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-[[ (E) -4- (Dimethylamino) but-2-enoyl]amino]-N-[4-[ (4-pyridin-3-ylpyrimidin-2-yl) amino]phenyl]benzamide

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