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AZ191

CAT: 0013-GTR19160482-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160482-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ191 is a novel, potent and selective DYRK1B inhibitor. AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr (286), not Thr (288) . AZ191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene. AZ191 may prove useful in defining further substrates and biological functions of DYRK1B.
CAS Number
1594092-37-1
Product Name Alternative
AZ191 | AZ-191 | AZ 191
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL. 69.85 mM; H2O : < 0.1 mg/mL
Smiles
CN1CCN (CC1) c1cc (c (cc1) Nc1nccc (n1) c1cn (c2c1ccnc2) C) OC
Molecular Formula
C24H27N7O
Molecular Weight
429.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (2-methoxy-4- (4-methylpiperazin-1-yl) phenyl) -4- (1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl) pyrimidin-2-amine

Chemical Information

AZ191
CAS Number1594092-37-1
PubChem CID72716071
IUPAC NameN-[2-methoxy-4-(4-methylpiperazin-1-yl)phenyl]-4-(1-methylpyrrolo[2,3-c]pyridin-3-yl)pyrimidin-2-amine
Molecular FormulaC24H27N7O
Molecular Weight429.5
XLogP2.7
Topological Polar Surface Area71.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count32
Formal Charge0
Complexity601
SMILES
CN1CCN(CC1)C2=CC(=C(C=C2)NC3=NC=CC(=N3)C4=CN(C5=C4C=CN=C5)C)OC
InChI
InChI=1S/C24H27N7O/c1-29-10-12-31(13-11-29)17-4-5-21(23(14-17)32-3)28-24-26-9-7-20(27-24)19-16-30(2)22-15-25-8-6-18(19)22/h4-9,14-16H,10-13H2,1-3H3,(H,26,27,28)
InChIKey
ZYVXTMKTGDARKR-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of AZ191
CAS: 1594092-37-1
CID: 72716071
Formula: C24H27N7O
MW: 429.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight429.5
XLogP32.7
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass429.22770851
Monoisotopic Mass429.22770851
Topological Polar Surface Area71.3 Ų
Heavy Atom Count32
Formal Charge0
Complexity601
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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