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AZ191

CAT: 0013-GTR19160482-01Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160482-01Size:100 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ191 is a novel, potent and selective DYRK1B inhibitor. AZ191 demonstrates that DYRK1B acts independently of GSK3β to phosphorylate cyclin D1 at Thr (286), not Thr (288) . AZ191 selectively inhibits DYRK1B in vitro and in cells. DYRK1B (dual-specificity tyrosine phosphorylation-regulated kinase 1B) is amplified in certain cancers and may be an oncogene. AZ191 may prove useful in defining further substrates and biological functions of DYRK1B.
CAS Number
1594092-37-1
Product Name Alternative
AZ191 | AZ-191 | AZ 191
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL. 69.85 mM; H2O : < 0.1 mg/mL
Smiles
CN1CCN (CC1) c1cc (c (cc1) Nc1nccc (n1) c1cn (c2c1ccnc2) C) OC
Molecular Formula
C24H27N7O
Molecular Weight
429.52
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
N- (2-methoxy-4- (4-methylpiperazin-1-yl) phenyl) -4- (1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl) pyrimidin-2-amine

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