Products for Research Use Only

Tebipenem Pivoxil

CAT: 0013-GTR19160476-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160476-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Tebipenem pivoxil, also known as ME1211; SPR994 and TBM-PI, is a novel oral carbapenem antibiotic. TBM-PI is a promising antibiotic for the treatment of acute otitis media. Tebipenem pivoxil displays an excellent antibacterial activity against a variety of pathogenic bacteria in vitro. Importantly, tebipenem pivoxil significantly protects the sepsis mice challenged with various pathogenic bacteria, which may provide a potential approach to treating bacterial sepsis in clinic. (In Vitro) :Tebipenem pivoxil (0-128 μg/mL; 18–24 h) displays excellent antibacterial activity against a variety of pathogenic bacteria. (In Vivo) :Tebipenem pivoxil (L084) (0-4.00 g/kg; p.o.; once) shows minimal lethal dosage (MLD) of 4.00 g/kg and the maximum tolerance dosage (MTD) of 3.40 g/kg in mice.Tebipenem pivoxil (50 and 100 mg/kg; p.o.; once) significantly protects the sepsis mice challenged with various pathogenic bacteria.
CAS Number
161715-24-8
Product Name Alternative
ME1211 | SPR994 | TBM-PI | Tebipenem pivoxil
Field of Research
Pharmacology & Drug Discovery
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 150 mg/mL; 301.43 mM
Smiles
C[C@@H]1[C@@H]2[C@H] (C (=O) N2C (=C1SC1CN (C1) C1=NCCS1) C (=O) OCOC (=O) C (C) (C) C) [C@@H] (C) O
Molecular Formula
C22H31N3O6S2
Molecular Weight
497.63
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(pivaloyloxy) methyl (4R,5R,6S) -3- ((1- (4,5-dihydrothiazol-2-yl) azetidin-3-yl) thio) -6- ((R) -1-hydroxyethyl) -4-methyl-7-oxo-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylate