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AZ6102

CAT: 0013-GTR19160463-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160463-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AZ6102 is a potent TNKS1/2 inhibitor that has 100-fold selectivity against other PARP family enzymes and shows 5 nM Wnt pathway inhibition in DLD-1 cells. AZ6102 can be formulated well in a clinically relevant intravenous solution at 20 mg/mL, has demonstrated good pharmacokinetics in preclinical species, and shows low Caco2 efflux to avoid possible tumor resistance mechanisms. The canonical Wnt pathway plays an important role in embryonic development, adult tissue homeostasis, and cancer. Germline mutations of several Wnt pathway components, such as Axin, APC, and -catenin, can lead to oncogenesis. Inhibition of the poly (ADP-ribose) polymerase (PARP) catalytic domain of the tankyrases (TNKS1 and TNKS2) is known to inhibit the Wnt pathway via increased stabilization of Axin.
CAS Number
1645286-75-4
Product Name Alternative
AZ6102 | AZ-6102 | AZ 6102
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 29 mg/mL; 67.67 mM
Smiles
C[C@@H]1CN (c2ncc (c3ccc (c4nc (=O) c5ccn (C) c5[nH]4) cc3) c (C) c2) C[C@H] (C) N1
Molecular Formula
C25H28N6O
Molecular Weight
428.53
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
2- (4- (6- ((3R,5S) -3,5-dimethylpiperazin-1-yl) -4-methylpyridin-3-yl) phenyl) -7-methyl-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one

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