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AN2718

CAT: 0013-GTR19160449-02Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160449-02Size:5 mg
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Description
AN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS. This enzyme plays an essential role in fungal protein synthesis by attaching the leucine amino acid to transfer RNA, or tRNA. AN2718, an investigational topical anti-fungal product candidate for the potential treatment of skin and nail infections. At various concentrations, AN2718 gel showed low irritation potential, leading investigators to conclude that application site reactions in future efficacy trials would be unlikely. (In Vitro) :AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes.
CAS Number
174672-06-1
Product Name Alternative
AN2718 | AN-2718 | AN 2718
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 50 mg/mL (296.93 mM)
Smiles
C12c (ccc (c1) Cl) B (OC2) O
Molecular Formula
C7H6BClO2
Molecular Weight
168.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-chlorobenzo[c][1,2]oxaborol-1 (3H) -ol

Chemical Information

An-2718

An2718 has been used in trials studying Tinea Pedis.

CAS Number174672-06-1
PubChem CID11845944
IUPAC Name5-chloro-1-hydroxy-3H-2,1-benzoxaborole
Molecular FormulaC7H6BClO2
Molecular Weight168.39
Topological Polar Surface Area29.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Heavy Atom Count11
Formal Charge0
Complexity155
SMILES
B1(C2=C(CO1)C=C(C=C2)Cl)O
InChI
InChI=1S/C7H6BClO2/c9-6-1-2-7-5(3-6)4-11-8(7)10/h1-3,10H,4H2
InChIKey
HMAFTPZYFJFEHK-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of An-2718
CAS: 174672-06-1
CID: 11845944
Formula: C7H6BClO2
MW: 168.39
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight168.39
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count2
Rotatable Bond Count0
Exact Mass168.0149373
Monoisotopic Mass168.0149373
Topological Polar Surface Area29.5 Ų
Heavy Atom Count11
Formal Charge0
Complexity155
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BA1681-25AN2718
A16203-100AN2718 100mg
A16203-50AN2718 50mg
A16203-500AN2718 500mg
A16203-25AN2718 25mg
A16203-10AN2718 10mg
A16203-5AN2718 5mg
A16203-10mM-DAN2718 10mM * 1mL in DMSO

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