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AN2718

CAT: 0013-GTR19160449-01Size: 1 gDry Ice: NoHazardous: No
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CAT#:0013-GTR19160449-01Size:1 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
AN2718 is a novel boron-containing small molecule that inhibits an essential protein synthesis enzyme, leucyl-transfer RNA synthetase, or LeuRS. This enzyme plays an essential role in fungal protein synthesis by attaching the leucine amino acid to transfer RNA, or tRNA. AN2718, an investigational topical anti-fungal product candidate for the potential treatment of skin and nail infections. At various concentrations, AN2718 gel showed low irritation potential, leading investigators to conclude that application site reactions in future efficacy trials would be unlikely. (In Vitro) :AN2718 inhibits cytoplasmic LeuRS from molds, A. fumigatus, and from yeasts, C. albicans, with an IC50 of 2 μM and 4.2 μM, respectively. AN2718 has good MIC90 activity against the dermatophytes, T. rubrum and T.mentagrophytes.
CAS Number
174672-06-1
Product Name Alternative
AN2718 | AN-2718 | AN 2718
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : ≥ 50 mg/mL (296.93 mM)
Smiles
C12c (ccc (c1) Cl) B (OC2) O
Molecular Formula
C7H6BClO2
Molecular Weight
168.4
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
5-chlorobenzo[c][1,2]oxaborol-1 (3H) -ol

Alternative Products

CatalogName
BA1681-25AN2718
A16203-100AN2718 100mg
A16203-50AN2718 50mg
A16203-500AN2718 500mg
A16203-25AN2718 25mg
A16203-10AN2718 10mg
A16203-5AN2718 5mg
A16203-10mM-DAN2718 10mM * 1mL in DMSO

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