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Emapunil

CAT: 0013-GTR19160386-02Size: 2 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160386-02Size:2 mg
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Description
Emapunil is an anxiolytic drug which acts as a selective agonist at the peripheral benzodiazepine receptor, also known as the mitochondrial 18 kDa translocator protein or TSPO. (In Vivo) :Emapunil (AC-5216, 0.1-3, 0.003-0.01 and 0.01-0.3 mg/kg, p.o.) produces anti-anxiety effects in the Vogel-type conflict test in rats, and in the light/dark box and social interaction tests in mice.Emapunil (AC-5216, 3-30 mg/kg, p.o.) reduces the immobility time, and this effect was blocked by PK11195.Emapunil (AC-5216, 1-100 mg/kg, p.o.) produces no distinct change in the rat electroencephalogram.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) causes significant suppression of the enhanced anxiety and contextual fear induced in post-TDS rats.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) alleviates the enhanced anxiety and fear response in a time-dependent sensitization (TDS) procedure, a rat PTSD animal model.Emapunil (AC-5216, 0.3 and 1 mg/kg, i.g.) reverses the increased plasma glucose (PG) and decreased insulin (INS) in HFD-STZ rats.
CAS Number
226954-04-7
Product Name Alternative
AC-5216 | XBD-173
Purity
>98% (HPLC)
Solubility
DMSO : 33.33 mg/mL 83.02 mM
Smiles
CCN (Cc1ccccc1) C (=O) Cn1c2nc (ncc2n (c1=O) C) c1ccccc1
Molecular Formula
C23H23N5O2
Molecular Weight
401.46
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

Chemical Information

Emapunil

Emapunil is an organic molecular entity. It has a role as an anxiolytic drug.

CAS Number226954-04-7
PubChem CID6433109
IUPAC NameN-benzyl-N-ethyl-2-(7-methyl-8-oxo-2-phenylpurin-9-yl)acetamide
Molecular FormulaC23H23N5O2
Molecular Weight401.5
XLogP2.6
Topological Polar Surface Area69.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Heavy Atom Count30
Formal Charge0
Complexity602
SMILES
CCN(CC1=CC=CC=C1)C(=O)CN2C3=NC(=NC=C3N(C2=O)C)C4=CC=CC=C4
InChI
InChI=1S/C23H23N5O2/c1-3-27(15-17-10-6-4-7-11-17)20(29)16-28-22-19(26(2)23(28)30)14-24-21(25-22)18-12-8-5-9-13-18/h4-14H,3,15-16H2,1-2H3
InChIKey
NBMBIEOUVBHEBM-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Emapunil
CAS: 226954-04-7
CID: 6433109
Formula: C23H23N5O2
MW: 401.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight401.5
XLogP32.6
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass401.18517499
Monoisotopic Mass401.18517499
Topological Polar Surface Area69.6 Ų
Heavy Atom Count30
Formal Charge0
Complexity602
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

Alternative Products

CatalogName
BUP11597-01Emapunil
HY-15527R-01Emapunil (Standard)
C08700-5mgEmapunil (AC 5216)
MBS387635-01AC-5216 (Emapunil)
A13138-200AC-5216 (Emapunil) 200mg
A13138-5AC-5216 (Emapunil) 5mg
A13138-1AC-5216 (Emapunil) 1mg
A13138-100AC-5216 (Emapunil) 100mg
228028Emapunil (AC-5216, XBD-173)
A13138-10mM-DAC-5216 (Emapunil) 10mM * 1mL in DMSO

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