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SU6656

CAT: 0013-GTR19160354-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160354-01Size:200 mg
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Description
SU6656 is a potent and selective dual inhibitor of Src family kinases and Aurora kinase. SU6656 modulates CTGF (connective tissue growth factor) expression in an ERK-dependent manner. SU6656 induces caspase-independent cell death in FRO anaplastic thyroid carcinoma cells and therapeutic synergy in human synovial sarcoma growth, invasion and angiogenesis in vivo.
CAS Number
330161-87-0
Product Name Alternative
SU6656 | SU 6656 | SU-6656
Purity
>98% (HPLC)
Solubility
DMSO : 18.5 mg/mL. 49.80 mM
Smiles
CN (C) S (=O) (=O) c1cc2c (cc1) NC (=O) /C/2=C\c1cc2c ([nH]1) CCCC2
Molecular Formula
C19H21N3O3S
Molecular Weight
371.45
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(Z) -N, N-dimethyl-2-oxo-3- ((4,5,6,7-tetrahydro-1H-indol-2-yl) methylene) indoline-5-sulfonamide

Chemical Information

2,3-dihydro-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-1H-Indole-5-sulfonamide

SU6656 is a member of the class of oxindoles that is 3-methyleneoxindole in which the hydrogeh at position 5 has been replaced by a dimethylaminosulfonyl group and in which one of the hydrogens of the methylene group has been replaced by a 4,5,6,7-tetrahydro-indol-2-yl group. It is a specific inhibitor of Src family kinase. It has a role as an antineoplastic agent, an Aurora kinase inhibitor and an EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor. It is a sulfonamide and a member of oxindoles.

CAS Number330161-87-0
PubChem CID5309
IUPAC NameN,N-dimethyl-2-oxo-3-(4,5,6,7-tetrahydro-1H-indol-2-ylmethylidene)-1H-indole-5-sulfonamide
Molecular FormulaC19H21N3O3S
Molecular Weight371.5
XLogP2.1
Topological Polar Surface Area90.7
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity697
SMILES
CN(C)S(=O)(=O)C1=CC2=C(C=C1)NC(=O)C2=CC3=CC4=C(N3)CCCC4
InChI
InChI=1S/C19H21N3O3S/c1-22(2)26(24,25)14-7-8-18-15(11-14)16(19(23)21-18)10-13-9-12-5-3-4-6-17(12)20-13/h7-11,20H,3-6H2,1-2H3,(H,21,23)
InChIKey
LOGJQOUIVKBFGH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 2,3-dihydro-N,N-dimethyl-2-oxo-3-((4,5,6,7-tetrahydro-1H-indol-2-yl)methylene)-1H-Indole-5-sulfonamide
CAS: 330161-87-0
CID: 5309
Formula: C19H21N3O3S
MW: 371.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight371.5
XLogP32.1
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count3
Exact Mass371.13036271
Monoisotopic Mass371.13036271
Topological Polar Surface Area90.7 Ų
Heavy Atom Count26
Formal Charge0
Complexity697
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count1
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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