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C29

CAT: 0013-GTR19160341-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160341-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
TLR2-IN-C29 is an inhibitor of TLR2/1 and TLR2/6 signaling. It is induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages. (In Vitro) :C29 (10 or 50 μΜ; 1 hour) blocks P3C- and P2C-induced IL-8 mRNA dose-dependently in HEK-TLR2 stable transfectants. C29 (50-200 μM; 1 hour) inhibits P3C- and P2C-induced IL-1β gene expression significantly at both 1 h and 4 h following stimulation in THP-1 cells.C29 (25 or 50 μΜ; 1 hour) reduces P3C-induced but not P2C-induced TNF-α mRNA and IL-12 p40 protein significantly in primary murine macrophages.C29 (50 μΜ; 1 hour) blocks TLR2 bacterial agonist-induced proinflammatory gene expression in HEK-TLR2 cells and murine macrophages.
CAS Number
363600-92-4
Product Name Alternative
TLR2-IN-C29 | TLR2 IN C29 | TLR2INC29 | TLR2-inhibitor-C29
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 30 mg/mL; 105.16 mM
Smiles
COc1cccc (\C=N\c2cccc (C (O) =O) c2C) c1O
Molecular Formula
C16H15NO4
Molecular Weight
285.3
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
3-[[ (2-Hydroxy-3-methoxyphenyl) methylene]amino]-2-methyl-benzoic acid

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