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Glabridin

CAT: 0013-GTR19160289-04Size: 100 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160289-04Size:100 mg
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Description
Glabridin may serve as an anti-inflammatory agent in diabetes-related vascular dysfunction, through regulating the synthesis and activity of iNOS under high-glucose levels; may possess a therapeutic effect on metabolic disorders (such as diabetes and hyperglycemia), by modulating glucose metabolism through AMPK in skeletal muscle cells. Glabridin may have potential as a chemopreventive agent against liver Y metastasis, by inhibiting the invasion of human HCC cells.
CAS Number
59870-68-7
Product Name Alternative
Glabridin | Q-100692 | KB289522 | S-176045
Purity
>98% (HPLC)
Solubility
DMSO : 150 mg/mL. 462.43 mM
Smiles
CC1 (C=Cc2c (O1) ccc1c2OC[C@H] (C1) c1c (cc (cc1) O) O) C
Molecular Formula
C20H20O4
Molecular Weight
324.37
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(R) -4- (8,8-dimethyl-3,4-dihydro-2H,8H-pyrano[2,3-f]chromen-3-yl) benzene-1,3-diol

Chemical Information

Glabridin

Glabridin is a member of the class of hydroxyisoflavans that is (R)-isoflavan substituted by hydroxy groups at positions 2' and 4' and a 2,2-dimethyl-2H-pyran group across positions 7 and 8 respectively. It has a role as an antiplasmodial drug. It derives from a hydride of a (R)-isoflavan.

CAS Number59870-68-7
PubChem CID124052
IUPAC Name4-[(3R)-8,8-dimethyl-3,4-dihydro-2H-pyrano[2,3-f]chromen-3-yl]benzene-1,3-diol
Molecular FormulaC20H20O4
Molecular Weight324.4
XLogP3.9
Topological Polar Surface Area58.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Heavy Atom Count24
Formal Charge0
Complexity488
SMILES
CC1(C=CC2=C(O1)C=CC3=C2OC[C@H](C3)C4=C(C=C(C=C4)O)O)C
InChI
InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1
InChIKey
LBQIJVLKGVZRIW-ZDUSSCGKSA-N
Chemical Structure
2D Structure
2D structure of Glabridin
CAS: 59870-68-7
CID: 124052
Formula: C20H20O4
MW: 324.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight324.4
XLogP33.9
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count4
Rotatable Bond Count1
Exact Mass324.13615911
Monoisotopic Mass324.13615911
Topological Polar Surface Area58.9 Ų
Heavy Atom Count24
Formal Charge0
Complexity488
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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