VCMMAE

CAT: 0013-GTR19160281-01Size: 200 mgDry Ice: NoHazardous: No

1 / 1

CAT#:0013-GTR19160281-01Size:200 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Description

VcMMAE is a MMAE derivative with valine-citrulline (Vc) linker. VcMMAE can be used to make antibody drug conjugate. VcMMAE is a anti-mitotic agent, monomethyl auristatin E (MMAE), linked via the lysosomally cleavable dipeptide, valine-citrulline (vc) . Monomethyl auristatin E (MMAE) is a synthetic antineoplastic agent. Because of its toxicity, it cannot be used as a drug itself; instead, it is linked to a monoclonal antibody (MAB) which directs it to the cancer cells. In International Nonproprietary Names for MMAE-MAB-conjugates, the name vedotin refers to MMAE plus its linking structure to the antibody. It is a potent antimitotic drug derived from peptides occurring in marine shell-less mollusc Dolabella auricularia called dolastatins which show potent activity in preclinical studies, both in vitro and in vivo, against a range of lymphomas, leukemia and solid tumors. These drugs show potency of up to 200 times that of vinblastine, another antimitotic drug used for Hodgkin lymphoma as well as other types of cancer.

CAS Number

646502-53-6

Product Name Alternative

VcMMAE | Vc-MMAE | MMAE Vc linker

Purity

>98% (HPLC)

Solubility

DMSO : ≥ 54 mg/mL; 41.01 mM

Smiles

CC[C@H] (C) [C@@H] ([C@@H] (CC (=O) N1CCC[C@H]1[C@H] (OC) [C@@H] (C) C (=O) N[C@H] (C) [C@@H] (O) c1ccccc1) OC) N (C) C (=O) [C@@H] (NC (=O) [C@H] (C (C) C) N (C) C (=O) OCc1ccc (NC (=O) [C@H] (CCCNC (N) =O) NC (=O) [C@@H] (NC (=O) CCCCCN2C (=O) C=CC2=O) C (C) C) cc1) C (C) C

Molecular Formula

C68H105N11O15

Molecular Weight

1316.65

Storage Conditions

Storage temperature: -20°C. Stability: ≥ 2 years

Notes

For research use only.

Other Product Names

4- ((S) -2- ((S) -2- (6- (2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl) hexanamido) -3-methylbutanamido) -5-ureidopentanamido) benzyl ((S) -1- (((S) -1- (((3R,4S,5S) -1- ((S) -2- ((1R,2R) -3- (((1S,2R) -1-hydroxy-1-phenylpropan-2-yl) amino) -1-methoxy-2-methyl-3-oxopropyl) pyrrolidin-1-yl) -3-methoxy-5-methyl-1-oxoheptan-4-yl) (methyl) amino) -3-methyl-1-oxobutan-2-yl) amino) -3-methyl-1-oxobutan-2-yl) (methyl) carbamate

Alternative Products

Catalog	Name
WAB50253-01	VcMMAE
HY-15575R-01	VcMMAE (Standard)
T201614-01	VcMMAE-Deruxtecan
A14362-100	VcMMAE 100mg
A14362-1	VcMMAE 1mg
A14362-50	VcMMAE 50mg
HY-164837-01	VcMMAE-Eribulin
A14362-500	VcMMAE 500mg
A14362-25	VcMMAE 25mg
A14362-10	VcMMAE 10mg

VCMMAE

Alternative Products

Popular Products