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KW-2478

CAT: 0013-GTR19160237-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160237-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
KW-2478 is a non-ansamycin HSP90 inhibitor with IC50 of 3.8 nM. (In Vitro) :KW-2478 is an inhibitor of Hsp90, with an IC50 of 3.8 nM for Hsp90α. KW-2478 shows anti-proliferative activity against multiple myeloma (MM) and non-Hodgkin’s lymphoma (NHL), with GI50s of 0.30 μM (OPM-2/GFP), 0.34 μM (KMS-11), 0.39 μM (RPMI 8226), 0.12 μM (NCI-H929), 0.36 μM (Raji), 0.098 μM (SR), and 0.33 μM μM (SC-1) . KW-2478 also inhibits the transcription of c-Maf and Cyclin D1 genes by mainly suppressing the function of Cdk9. (In Vivo) :KW-2478 (25-200 mg/kg, i.v.) inhibits tumor growth in combined immunodeficiency (SCID) mice bearing NCI-H929 cells, without body weight loss. KW-2478 (100 mg/kg, i.v.) causes degradation of the Hsp90 client proteins (IGF-1Rβ, c-Raf-1, Cdk9) levels and dephosphorylated Erk1/2 proteins in NCI-H929 tumors of mice.
CAS Number
819812-04-9
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 83.3 mg/mL; 144.96 mM
Smiles
CCc1c (O) cc (O) c (C (=O) c2cc (OC) c (OCCN3CCOCC3) cc2) c1CC (=O) N (CCOC) CCOC
Molecular Formula
C30H42N2O9
Molecular Weight
574.66
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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