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SSR128129E

CAT: 0013-GTR19160230-02Size: 500 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160230-02Size:500 mg
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Description
SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Inhibition by SSR128129E is highly conserved throughout the animal kingdom. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment.
CAS Number
848318-25-2
Product Name Alternative
SSR128129E | SSR 128129E
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 54 mg/mL; 155.93 mM
Smiles
Cc1c (n2ccccc2c1OC) C (=O) c1cc (c (cc1) N) C (=O) [O-].[Na+]
Molecular Formula
C18H15N2O4·Na
Molecular Weight
346.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sodium 2-amino-5- (1-methoxy-2-methylindolizine-3-carbonyl) benzoate

Chemical Information

Ssr128129E

Sodium 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate is an organic sodium salt having 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate as the counterion. It has a role as an antineoplastic agent and a fibroblast growth factor receptor antagonist. It contains a 2-amino-5-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]benzoate.

CAS Number848318-25-2
PubChem CID68853159
IUPAC Namesodium 2-amino-5-(1-methoxy-2-methylindolizine-3-carbonyl)benzoate
Molecular FormulaC18H15N2NaO4
Molecular Weight346.3
Topological Polar Surface Area96.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count25
Formal Charge0
Complexity503
SMILES
CC1=C(N2C=CC=CC2=C1OC)C(=O)C3=CC(=C(C=C3)N)C(=O)[O-].[Na+]
InChI
InChI=1S/C18H16N2O4.Na/c1-10-15(20-8-4-3-5-14(20)17(10)24-2)16(21)11-6-7-13(19)12(9-11)18(22)23;/h3-9H,19H2,1-2H3,(H,22,23);/q;+1/p-1
InChIKey
JFBMSTWZURKQOC-UHFFFAOYSA-M
Chemical Structure
2D Structure
2D structure of Ssr128129E
CAS: 848318-25-2
CID: 68853159
Formula: C18H15N2NaO4
MW: 346.3
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight346.3
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass346.09295125
Monoisotopic Mass346.09295125
Topological Polar Surface Area96.9 Ų
Heavy Atom Count25
Formal Charge0
Complexity503
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count2
Compound Is CanonicalizedYes

Alternative Products

CatalogName
B1525-20SSR128129E
A13211-50SSR128129E 50mg
A13211-2SSR128129E 2mg

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