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SSR128129E

CAT: 0013-GTR19160230-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160230-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SSR128129E (SSR) is an potent FGFR inhibitor, which inhibits fibroblast growth factor receptor (FGFR) signaling by binding to the extracellular FGFR domain without affecting orthosteric FGF binding. SSR128129E exhibits allosteric properties, including probe dependence, signaling bias, and ceiling effects. Inhibition by SSR128129E is highly conserved throughout the animal kingdom. Oral delivery of SSR128129E inhibits arthritis and tumors that are relatively refractory to anti-vascular endothelial growth factor receptor-2 antibodies. Thus, orally-active extracellularly acting small-molecule modulators of RTKs with allosteric properties can be developed and may offer opportunities to improve anticancer treatment.
CAS Number
848318-25-2
Product Name Alternative
SSR128129E | SSR 128129E
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 54 mg/mL; 155.93 mM
Smiles
Cc1c (n2ccccc2c1OC) C (=O) c1cc (c (cc1) N) C (=O) [O-].[Na+]
Molecular Formula
C18H15N2O4·Na
Molecular Weight
346.31
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
Sodium 2-amino-5- (1-methoxy-2-methylindolizine-3-carbonyl) benzoate

Alternative Products

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B1525-20SSR128129E
A13211-50SSR128129E 50mg
A13211-2SSR128129E 2mg

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