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BMS-582949 HCl

CAT: 0013-GTR19160188-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160188-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
The BMS-582949 hydrochloride is a highly specific p38α MAPK inhibitor (IC50: 13 nM) . (In Vitro) :BMS-582949 displays a p38α IC50 of 13 nM and a cellular TNFα IC50 of 50 nM.BMS-582949 is a weak inhibitor of CYP3A4 BMS-582949 displays >2000-fold selectivity for p38α over a diverse panel of 57 kinases that include serine kinases, nonreceptor tyrosine kinases, receptor tyrosine kinases, and the p38γ and δ isoforms. (In Vivo) :BMS-582949 (5-100 mg/kg, orally) is effective in both the acute murine model of inflammation and rat adjuvant arthritis model despite its slightly reduced potency.
CAS Number
912806-16-7
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 35 mg/mL; 79.02 mM
Smiles
N12ncnc (c1c (c (c2) C (=O) NCCC) C) Nc1c (ccc (c1) C (=O) NC1CC1) C.Cl
Molecular Formula
C22H27ClN6O2
Molecular Weight
442.95
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.

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