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QS 11

CAT: 0013-GTR19160163-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19160163-01Size:200 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
QS 11 is a GTPase activating protein of ADP-ribosylation factor 1 (ARFGAP1) inhibitor. Modulates ARF-GTP levels and synergizes with the Wnt/β-catenin signaling pathway to upregulate β-catenin nuclear translocation. Also reduces in vitro migration of metastatic human breast cancer cells. (In Vitro) :QS11 binds and inhibits the GTPase activating protein of ARFGAP1, suggesting that QS11 modulates Wnt/β-catenin signaling through an effect on protein trafficking.QS11 (2.5 μM) activates the Super (8X) TOPFlash reporter 200-fold in the presence of Wnt-3a conditioned medium, whereas Wnt-3a treatment alone increases reporter activity 40-fold.QS11 shows potent activity (EC50=0.5 μM) with little cytotoxicity toward HEK293 and human primary fibroblast cells.QS11 effectively reduces in vitro migration of metastatic human breast cancer cells.
CAS Number
944328-88-5
Product Name Alternative
QS11 | QS-11 | QS 11
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 176.16 mM; H2O : < 0.1 mg/mL
Smiles
OC[C@H] (Cc1ccccc1) Nc1c2c (n (Cc3ccc (c4ccccc4) cc3) cn2) nc (Oc2ccc3CCCc3c2) n1
Molecular Formula
C36H33N5O2
Molecular Weight
567.7
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
(2S) -2-[[2- (2,3-Dihydro-1H-inden-5-yloxy) -9-[ (4-phenylphenyl) methyl]purin-6-yl]amino]-3-phenylpropan-1-ol

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