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C-DIM12

CAT: 0013-GTR19159966-03Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159966-03Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
C-DIM12 is a novel synthetic activator of Nurr1. C-DIM12 induces dopaminergic gene expression and protects against 6-hydroxydopamine neurotoxicity in vitro. C-DIM12 activates Nurr1 in cancer cells and prevents loss of dopaminergic neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) model of PD in mice. C-DIM12 induced expression of Nurr1-regulated genes that was abolished by Nurr1 knockdown. C-DIM12 increased expression of transfected human Nurr1, induced Nurr1 protein expression in primary dopaminergic neurons and enhanced neuronal survival from exposure to 6-OHDA. C-DIM12 stimulates neuroprotective expression Nurr1-regulated genes in DA neurons.
CAS Number
178946-89-9
Product Name Alternative
C-DIM12 | C-DIM 12 | C-DIM-12
Purity
>98% (HPLC)
Solubility
DMSO : ≥ 100 mg/mL 280.23 mM; H2O : < 0.1 mg/mL
Smiles
Clc1ccc (C (c2c[nH]c3c2cccc3) c2c[nH]c3c2cccc3) cc1
Molecular Formula
C23H17ClN2
Molecular Weight
356.85
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
1,1-bis (3-indolyl) -1- (p-chlorophenyl) methane

Chemical Information

3-[(4-chlorophenyl)-(1H-indol-3-yl)methyl]-1H-indole
CAS Number178946-89-9
PubChem CID5302583
IUPAC Name3-[(4-chlorophenyl)-(1H-indol-3-yl)methyl]-1H-indole
Molecular FormulaC23H17ClN2
Molecular Weight356.8
XLogP6.2
Topological Polar Surface Area31.6
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count0
Rotatable Bond Count3
Heavy Atom Count26
Formal Charge0
Complexity443
SMILES
C1=CC=C2C(=C1)C(=CN2)C(C3=CC=C(C=C3)Cl)C4=CNC5=CC=CC=C54
InChI
InChI=1S/C23H17ClN2/c24-16-11-9-15(10-12-16)23(19-13-25-21-7-3-1-5-17(19)21)20-14-26-22-8-4-2-6-18(20)22/h1-14,23,25-26H
InChIKey
LTLRXTDMXOFBDW-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 3-[(4-chlorophenyl)-(1H-indol-3-yl)methyl]-1H-indole
CAS: 178946-89-9
CID: 5302583
Formula: C23H17ClN2
MW: 356.8
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight356.8
XLogP36.2
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count0
Rotatable Bond Count3
Exact Mass356.1080262
Monoisotopic Mass356.1080262
Topological Polar Surface Area31.6 Ų
Heavy Atom Count26
Formal Charge0
Complexity443
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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