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Harpagoside

CAT: 0013-GTR19159928-01Size: 200 mgDry Ice: NoHazardous: No
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CAT#:0013-GTR19159928-01Size:200 mg
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Description
Harpagoside is an anti-inflammatory small molecule natural product originally isolated from the Harpagophytum procumbens (Devil ’s Claw) root, but can be isolated from other plants such as Crophularia ningpoensis Hemsl (Figwort) . Treatment of HepG2 cells with Harpagoside demonstrated suppression of NF-κB nuclear translocation and degradation of IκB-α, blocking NF-κB activation. Multiple anti-inflammatory cellular effects were correlated with this blockade, as Harpagoside was observed to inhibit the expression of inflammation-mediating enzymes cyclooxygenase-2 (COX-2) and inducible nitric oxide synthase (iNOS), and to reduce lipopolysaccharide-induced mRNA levels. The suppression of NF-κB activation is indicated as the mechanism beneath the anti-inflammatory effects of Harpagoside.
CAS Number
19210-12-9
Product Name Alternative
SMR001233395 | Eharpagoside
Purity
>98% (HPLC)
Solubility
In Vitro: DMSO : 62.5 mg/mL (126.39 mM)
Smiles
CC1 (CC (C2 (C1C (OC=C2) OC3C (C (C (C (O3) CO) O) O) O) O) O) OC (=O) C=CC4=CC=CC=C4
Molecular Formula
C24H30O11
Molecular Weight
494.49
Storage Conditions
Storage temperature: -20°C. Stability: ≥ 2 years
Notes
For research use only.
Other Product Names
[ (1S,4aS,5R,7S,7aS) -4a,5-dihydroxy-7-methyl-1-[ (2S,3R,4S,5S,6R) -3,4,5-trihydroxy-6- (hydroxymethyl) oxan-2-yl]oxy-1,5,6,7a-tetrahydrocyclopenta[c]pyran-7-yl] (E) -3-phenylprop-2-enoate

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